Increlex(mecasermin)
Increlex (mecasermin) is a protein pharmaceutical. Mecasermin was first approved as Increlex on 2005-08-30. It has been approved in Europe to treat laron syndrome. The pharmaceutical is active against insulin-like growth factor I. In addition, it is known to target insulin-like growth factor 1 receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Increlex
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Mecasermin
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Increlex | mecasermin | Ipsen Biopharmaceuticals, Inc. | N-21839 RX | 2005-08-30 | 1 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hucord hscm-100 ampoule | unapproved drug other | 2019-12-23 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
mecasermin, Increlex, Ipsen Biopharmaceuticals, Inc. | |||
| 2112-08-30 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2170 | Injection, mecasermin, 1 mg |
Clinical
Clinical Trials
308 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acromegaly | D000172 | — | — | — | 4 | 8 | 6 | 12 | 30 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | 1 | 5 | 3 | 4 | 5 | 17 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 2 | — | 1 | 2 | 5 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 2 | 2 | 4 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 1 | — | 1 | — | 3 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | 1 | 1 | 2 |
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | 1 | 1 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | 1 | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | 1 | — | 2 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | — | — | — | 1 | — | 1 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 5 | 1 | — | 4 | 11 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 1 | — | 7 | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 4 | 1 | — | — | 6 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | 2 | 3 | 3 | — | 1 | 6 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | — | 1 | 1 | — | 3 | 5 |
| Growth disorders | D006130 | — | — | — | 2 | 3 | — | 1 | 5 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | 1 | — | 2 | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | — | 2 | 3 |
| Adrenocortical carcinoma | D018268 | — | — | 1 | 2 | 1 | — | — | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | 2 | — | 1 | 3 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 10 | 4 | — | — | 1 | 13 |
| Sarcoma | D012509 | — | — | 1 | 5 | — | — | 1 | 6 |
| Colorectal neoplasms | D015179 | — | — | 2 | 3 | — | — | 1 | 5 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 2 | — | — | 2 | 4 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 4 | — | — | — | 4 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | 1 | — | — | 3 | 4 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | — | — | 2 | 4 |
| Rectal neoplasms | D012004 | — | — | — | 3 | — | — | — | 3 |
| Healthy volunteers/patients | — | — | — | — | 1 | — | — | 2 | 3 |
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | — | — | 1 | 3 |
Show 62 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioma | D005910 | EFO_0000520 | — | 3 | — | — | — | — | 3 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 2 | — | — | — | 1 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 2 | 3 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 1 | — | — | — | — | 1 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | 1 | — | — | — | — | 1 |
| Female genital neoplasms | D005833 | — | — | 1 | — | — | — | — | 1 |
| Thoracic neoplasms | D013899 | — | — | 1 | — | — | — | — | 1 |
| Macular edema | D008269 | — | — | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 3 | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | — | — | 2 | 2 |
| Graves disease | D006111 | EFO_0004237 | E05.0 | — | — | — | — | 2 | 2 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | — | 2 | 2 |
| Pituitary dwarfism | D004393 | EFO_1001109 | E23.0 | — | — | — | — | 2 | 2 |
| Igg deficiency | D017099 | HP_0004315 | D80.3 | — | — | — | — | 2 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 2 | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
Show 65 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mecasermin |
| INN | mecasermin |
| Description | Mecasermin (INN) (brand name Increlex), also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity).
|
| Classification | Protein |
| Drug class | growth factors: insulin-like growth factors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201716 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB01277 |
| UNII ID | 7GR9I2683O (ChemIDplus, GSRS) |
Target
Agency Approved
IGF1
IGF1
Organism
Homo sapiens
Gene name
IGF1
Gene synonyms
IBP1
NCBI Gene ID
Protein name
insulin-like growth factor I
Protein synonyms
insulin-like growth factor 1 (somatomedin C), insulin-like growth factor IB, Mechano growth factor, MGF, Somatomedin-C
Uniprot ID
Mouse ortholog
Igf1 (16000)
insulin-like growth factor I (Q8C4U6)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
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Adverse Events
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854 adverse events reported
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