Maxacalcitol
Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor.
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
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Results first post date
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Commercial
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | 1 | — | 1 | 4 |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | 2 | 1 | — | 1 | 4 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | — | 2 | 1 | — | 1 | 4 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 2 | 1 | — | — | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | 1 | — | — | 3 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Maxacalcitol |
| INN | maxacalcitol |
| Description | Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor. |
| Classification | Small molecule |
| Drug class | vitamin D analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)OCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 103909-75-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL333950 |
| ChEBI ID | — |
| PubChem CID | 12019456 |
| DrugBank | — |
| UNII ID | N2UJM5NBF6 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VDR
VDR
Organism
Homo sapiens
Gene name
VDR
Gene synonyms
NR1I1
NCBI Gene ID
Protein name
vitamin D3 receptor
Protein synonyms
1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor
Uniprot ID
Mouse ortholog
Vdr (22337)
vitamin D3 receptor (Q922X0)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 354 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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56 adverse events reported
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