Maxacalcitol
Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor.
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Commercial
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Clinical
Clinical Trials
2246 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 3 | 5 | 4 | 1 | 12 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | — | 1 | 2 | — | 3 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | 1 | 2 | 3 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | 1 | 2 | 3 |
| Sclerosis | D012598 | — | — | — | — | — | 1 | 2 | 3 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | — | — | 1 | 1 | 2 |
| Polypoidal choroidal vasculopathy | D000092342 | — | — | — | — | — | 1 | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | 1 | — | 1 |
| Immunosuppression therapy | D007165 | — | — | — | — | — | 1 | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Choroidal neovascularization | D020256 | — | — | — | 1 | 3 | — | 2 | 5 |
| Macular edema | D008269 | — | — | — | — | 2 | — | 2 | 4 |
| Retinal diseases | D012164 | — | H35.9 | — | — | 1 | — | — | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | 1 | — | — | 1 |
| Retinal neovascularization | D015861 | — | H35.05 | — | — | 1 | — | — | 1 |
| Degenerative myopia | D047728 | — | H44.2 | — | — | 1 | — | — | 1 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | 1 | — | — | — | 1 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | 1 | — | — | — | 1 |
| Ornithine carbamoyltransferase deficiency disease | D020163 | EFO_0007409 | E72.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pathologic neovascularization | D009389 | — | — | — | — | — | — | 2 | 2 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 1 | 1 |
| Vision disorders | D014786 | — | H53.11 | — | — | — | — | 1 | 1 |
| Low vision | D015354 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Maxacalcitol |
| INN | maxacalcitol |
| Description | Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor. |
| Classification | Small molecule |
| Drug class | vitamin D analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)OCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 103909-75-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL333950 |
| ChEBI ID | — |
| PubChem CID | 12019456 |
| DrugBank | DB06272 |
| UNII ID | N2UJM5NBF6 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VDR
VDR
Organism
Homo sapiens
Gene name
VDR
Gene synonyms
NR1I1
NCBI Gene ID
Protein name
vitamin D3 receptor
Protein synonyms
1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor
Uniprot ID
Mouse ortholog
Vdr (22337)
vitamin D3 receptor (Q922X0)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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182,098 adverse events reported
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