Maxacalcitol
Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor.
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Commercial
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Clinical
Clinical Trials
2246 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 2 | 16 | 18 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | 6 | 7 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | 1 | 6 | 7 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 1 | 6 | 7 |
| Coronary disease | D003327 | — | — | — | — | — | 1 | 4 | 5 |
| St elevation myocardial infarction | D000072657 | — | — | — | — | — | 1 | 3 | 4 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | 1 | 1 | 2 |
| Optical coherence tomography | D041623 | — | — | — | — | — | 1 | 1 | 2 |
| Calcinosis | D002114 | — | — | — | — | — | 1 | 1 | 2 |
| Dual anti-platelet therapy | D000080903 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | — | 2 | — | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | — | — | — | 2 |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | 2 | — | — | — | 2 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | — | 2 | — | — | — | 2 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | 1 | — | — | — | 1 |
| Macular edema | D008269 | — | — | — | 1 | — | — | — | 1 |
| Edema | D004487 | — | R60.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 6 | 6 |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | — | — | — | 3 | 3 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | — | 2 | 2 |
| Coronary vasospasm | D003329 | EFO_0004225 | — | — | — | — | — | 2 | 2 |
| Minoca | D000088442 | — | — | — | — | — | — | 2 | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 2 | 2 |
| Arteriosclerosis | D001161 | EFO_0009086 | I70 | — | — | — | — | 2 | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 2 | 2 |
| Chronic limb-threatening ischemia | D000089802 | — | — | — | — | — | — | 2 | 2 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 2 | 2 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Maxacalcitol |
| INN | maxacalcitol |
| Description | Maxacalcitol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin D3 receptor. |
| Classification | Small molecule |
| Drug class | vitamin D analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)OCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 103909-75-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL333950 |
| ChEBI ID | — |
| PubChem CID | 12019456 |
| DrugBank | DB06272 |
| UNII ID | N2UJM5NBF6 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
VDR
VDR
Organism
Homo sapiens
Gene name
VDR
Gene synonyms
NR1I1
NCBI Gene ID
Protein name
vitamin D3 receptor
Protein synonyms
1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor
Uniprot ID
Mouse ortholog
Vdr (22337)
vitamin D3 receptor (Q922X0)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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182,098 adverse events reported
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