Mavoglurant
Mavoglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fragile x syndrome | D005600 | — | Q99.2 | 1 | 6 | 1 | — | — | 7 |
| Syndrome | D013577 | — | — | 1 | 6 | 1 | — | — | 7 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 8 | — | — | — | 8 |
| Dyskinesias | D020820 | HP_0002310 | G24 | — | 8 | — | — | — | 8 |
| Cocaine-related disorders | D019970 | — | F14 | 2 | 1 | — | — | — | 3 |
| Parkinsonian disorders | D020734 | HP_0001300 | G20.C | — | 3 | — | — | — | 3 |
| Movement disorders | D009069 | HP_0100022 | — | — | 3 | — | — | — | 3 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 2 | 1 | — | — | — | 3 |
| Alcohol drinking | D000428 | EFO_0004329 | — | 1 | 1 | — | — | — | 2 |
| Drug-induced dyskinesia | D004409 | EFO_1000904 | — | — | 1 | — | — | — | 1 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 1 | — | — | — | 1 |
| Compulsive personality disorder | D003193 | — | F60.5 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | 1 | — | — | — | — | 1 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | 1 | — | — | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mavoglurant |
| INN | mavoglurant |
| Description | Mavoglurant (developmental code name AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome and other conditions. It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGluR5).
|
| Classification | Small molecule |
| Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)N1CC[C@@H]2[C@H]1CCC[C@@]2(O)C#Cc1cccc(C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1636881-61-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3087515 |
| ChEBI ID | — |
| PubChem CID | 9926832 |
| DrugBank | — |
| UNII ID | GT0I9SV4F6 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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