Marstacimab
Hympavzi (marstacimab) is an antibody pharmaceutical. Marstacimab was first approved as Hympavzi on 2024-10-11. It is used to treat hemophilia a and hemophilia b in the USA. It is known to target tissue factor pathway inhibitor.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Hympavzi
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hympavzi | Biologic Licensing Application | 2025-09-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hemophilia a | EFO_0007267 | D006467 | D66 |
| hemophilia b | — | D002836 | D67 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | 2 | 2 | 3 | — | 1 | 8 |
| Hemophilia b | D002836 | — | D67 | — | — | 3 | — | — | 3 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Marstacimab |
| INN | marstacimab |
| Description | Marstacimab is an antibody pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3990039 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB17725 |
| UNII ID | 0UB3OA67O7 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TFPI
TFPI
Organism
Homo sapiens
Gene name
TFPI
Gene synonyms
LACI, TFPI1
NCBI Gene ID
Protein name
tissue factor pathway inhibitor
Protein synonyms
anti-convertin, EPI, Extrinsic pathway inhibitor, LACI, Lipoprotein-associated coagulation inhibitor, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Uniprot ID
Mouse ortholog
Tfpi (21788)
tissue factor pathway inhibitor (Q9Z2U8)
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 95 documents
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Safety
Black-box Warning
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Adverse Events
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