Selzentry, Celsentri(maraviroc)
Celsentri, Maraviroc, Selzentry (maraviroc) is a small molecule pharmaceutical. Maraviroc was first approved as Selzentry on 2007-08-06. It is used to treat HIV infections in the USA. It has been approved in Europe to treat HIV infections. The pharmaceutical is active against C-C chemokine receptor type 5.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Maraviroc, Selzentry (discontinued: Selzentry)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Maraviroc
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SELZENTRY | ViiV Healthcare | N-022128 RX | 2007-08-06 | 2 products, RLD, RS |
| SELZENTRY | ViiV Healthcare | N-208984 RX | 2016-11-04 | 1 products, RLD, RS |
Show 1 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hiv infections | EFO_0000764 | D015658 | B20 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MARAVIROC, SELZENTRY, VIIV HLTHCARE | |||
| 2024-04-30 | PED | ||
| 2023-10-30 | NPP | ||
Patent Expiration
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HCPCS
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Clinical
Clinical Trials
166 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 5 | 8 | 7 | 6 | 3 | 25 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 3 | 2 | 5 | 4 | 16 |
| Hiv | D006678 | — | O98.7 | — | 3 | — | 4 | 4 | 11 |
| Healthy volunteers/patients | — | — | — | 5 | — | — | 1 | — | 6 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | 3 | — | 3 |
| Hepatitis | D006505 | — | K75.9 | — | — | — | 3 | — | 3 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | — | 3 | — | 3 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | — | 1 | 2 | — | 3 |
| Hiv-2 | D015498 | — | — | — | — | — | 1 | 1 | 2 |
| Hepatitis b | D006509 | — | — | — | — | — | 2 | — | 2 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv-1 | D015497 | — | — | — | 1 | 3 | — | 1 | 5 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 1 | 1 | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | 1 | 1 | — | — | 1 |
| Aids dementia complex | D015526 | EFO_0002608 | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Kaposi sarcoma | D012514 | — | C46 | — | 1 | — | — | — | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | — | — | — | 2 | 4 |
| Communicable diseases | D003141 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Persistent infection | D000088562 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Maraviroc |
| INN | maraviroc |
| Description | Maraviroc is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells. It has a role as an antiviral drug, a chemokine receptor 5 antagonist and a HIV fusion inhibitor. It is an azabicycloalkane, an organofluorine compound, a member of triazoles and a monocarboxylic acid amide. |
| Classification | Small molecule |
| Drug class | antivirals; antivirals, chemokine receptor (CCR) antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 376348-65-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201187 |
| ChEBI ID | 63608 |
| PubChem CID | 3002977 |
| DrugBank | DB04835 |
| UNII ID | MD6P741W8A (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
Black-box warning for: Maraviroc, Selzentry
Adverse Events
Top Adverse Reactions
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2,760 adverse events reported
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