Mapracorat
Mapracorat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cataract | D002386 | EFO_0001059 | H26.9 | — | 1 | 4 | — | — | 5 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 4 | — | — | 5 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Conjunctivitis | D003231 | — | H10 | — | 1 | — | — | — | 1 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | 1 | — | — | — | 1 |
| Keratoconjunctivitis sicca | D007638 | EFO_1000906 | — | — | 1 | — | — | — | 1 |
| Dry eye syndromes | D015352 | — | H04.12 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Corneal endothelial cell loss | D055954 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mapracorat |
| INN | mapracorat |
| Description | Mapracorat is an aminoquinoline. |
| Classification | Small molecule |
| Drug class | glucocorticoid receptor agonists ( not glucocorticoids) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc2c(NC[C@](O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)cccc2n1 |
Identifiers
| PDB | — |
| CAS-ID | 887375-26-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103876 |
| ChEBI ID | — |
| PubChem CID | 24795088 |
| DrugBank | DB12041 |
| UNII ID | 145V79YBVP (ChemIDplus, GSRS) |
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 121 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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