Mapracorat
Mapracorat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against glucocorticoid receptor.
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Events Timeline
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YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 5 | — | — | — | 5 |
| Eczema | D004485 | — | L30.9 | — | 3 | — | — | — | 3 |
| Dermatitis | D003872 | — | L30.9 | — | 3 | — | — | — | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mapracorat |
| INN | mapracorat |
| Description | Mapracorat is an aminoquinoline. |
| Classification | Small molecule |
| Drug class | glucocorticoid receptor agonists ( not glucocorticoids) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc2c(NC[C@](O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)cccc2n1 |
Identifiers
| PDB | — |
| CAS-ID | 887375-26-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103876 |
| ChEBI ID | — |
| PubChem CID | 24795088 |
| DrugBank | DB12041 |
| UNII ID | 145V79YBVP (ChemIDplus, GSRS) |
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 121 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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