MOCETINOSTAT
Mocetinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 3, histone deacetylase 1, and histone deacetylase 2.
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Commercial
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Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 4 | — | — | — | 6 |
| Preleukemia | D011289 | — | — | 4 | 4 | — | — | — | 6 |
| Leukemia | D007938 | — | C95 | 3 | 4 | — | — | — | 6 |
| Lymphoma | D008223 | — | C85.9 | 3 | 5 | — | — | — | 6 |
| Syndrome | D013577 | — | — | 4 | 3 | — | — | — | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 3 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 3 | — | — | — | 3 |
| Hodgkin disease | D006689 | — | C81 | 1 | 3 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 3 | 2 | — | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | — | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Rhabdomyosarcoma | D012208 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MOCETINOSTAT |
| INN | mocetinostat |
| Description | Mocetinostat (MGCD0103) is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers including follicular lymphoma, Hodgkin's lymphoma and acute myelogenous leukemia.
|
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccccc1NC(=O)c1ccc(CNc2nccc(-c3cccnc3)n2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 726169-73-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL272980 |
| ChEBI ID | — |
| PubChem CID | 9865515 |
| DrugBank | DB11830 |
| UNII ID | A6GWB8T96J (ChemIDplus, GSRS) |
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Safety
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17 adverse events reported
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