MIVEBRESIB
Mivebresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4.
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FDA approval date
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Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MIVEBRESIB |
| INN | mivebresib |
| Description | Mivebresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4. |
| Classification | Small molecule |
| Drug class | extra-terminal motif (BET) family of bromodomain (BRD) proteins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1445993-26-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3987016 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | VR86R11J7J (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BRD4
BRD4
Organism
Homo sapiens
Gene name
BRD4
Gene synonyms
HUNK1
NCBI Gene ID
Protein name
bromodomain-containing protein 4
Protein synonyms
chromosome-associated protein, female sterile homeotic related gene 4, mitotic chromosome-associated protein, Protein HUNK1
Uniprot ID
Mouse ortholog
Brd4 (57261)
bromodomain-containing protein 4 (Q9ESU6)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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