MILATUZUMAB
Milatuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against HLA class II histocompatibility antigen gamma chain.
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YTD
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FDA approval date
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Patent expiration date
Study first post date
Last update post date
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Commercial
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 5 | 3 | — | — | — | 5 |
| Leukemia | D007938 | — | C95 | 3 | 2 | — | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 2 | — | — | — | 3 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 2 | — | — | — | 3 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 2 | — | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 1 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | — | 2 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | 1 | — | — | — | 1 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 1 | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Discoid lupus erythematosus | D008179 | — | L93.0 | 1 | — | — | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | — | — | — | — | 1 |
| Central nervous system lupus vasculitis | D020945 | EFO_1001363 | — | 1 | — | — | — | — | 1 |
| Vasculitis | D014657 | EFO_0006803 | M31 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MILATUZUMAB |
| INN | milatuzumab |
| Description | Milatuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743040 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 2OP4E0GC6V (ChemIDplus, GSRS) |
Target
Agency Approved
CD74
CD74
Organism
Homo sapiens
Gene name
CD74
Gene synonyms
DHLAG
NCBI Gene ID
Protein name
HLA class II histocompatibility antigen gamma chain
Protein synonyms
CD74, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, class II MHC-associated invariant chain peptide, gamma chain of class II antigens, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ii, MHC HLA-DR gamma chain
Uniprot ID
Mouse ortholog
Cd74 (16149)
H-2 class II histocompatibility antigen gamma chain (P04441)
Alternate
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Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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