MERICITABINE
Mericitabine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 2 | 11 | — | — | — | 12 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 1 | 10 | — | — | — | 11 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | 1 | 10 | — | — | — | 11 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | 10 | — | — | — | 11 |
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | — | 3 |
| Hepacivirus | D016174 | — | — | 1 | 1 | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MERICITABINE |
| INN | mericitabine |
| Description | Mericitabine (RG-7128) is an antiviral drug, a deoxycytidine analog (a type of nucleoside analog). It was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor, but while it showed a good safety profile in clinical trials, it was not sufficiently effective to be used as a stand-alone agent. However mericitabine has been shown to boost the efficacy of other antiviral drugs when used alongside them, and as most modern treatment regimens for hepatitis C use a combination therapy of several antiviral drugs, clinical trials have continued to see if it can form a part of a clinically useful drug treatment program.
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| Classification | Small molecule |
| Drug class | nucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@](C)(F)[C@@H]1OC(=O)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 940908-79-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL562967 |
| ChEBI ID | — |
| PubChem CID | 16122663 |
| DrugBank | — |
| UNII ID | TA63JX8X52 (ChemIDplus, GSRS) |
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