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Drug ReportsLysine
Lysine
Ibuprofen, LysaKare, Neoprofen (lysine) is a small molecule pharmaceutical. Lysine was first approved as Neoprofen on 2006-04-13. It is used to treat nutritional and metabolic diseases in the USA. It has been approved in Europe to treat radiation injuries. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 1, G-protein coupled receptor family C group 6 member A, vasopressin V1b receptor, oxytocin receptor, sodium-coupled monocarboxylate transporter 1, nitric oxide synthase, inducible, peroxisome proliferator-activated receptor gamma, vasopressin V1a receptor, and vasopressin V2 receptor.
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Events Timeline
5D
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3M
6M
YTD
1Y
2Y
5Y
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FDA approval date
EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
wounds and injuriesD014947
physical phenomenaD055585
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
aminosyn iiNew Drug Application2022-05-04
aminosyn-pfNew Drug Application2022-07-21
clinimixNew Drug Application2021-04-13
clinimix eNew Drug Application2021-04-13
clinisolANDA2018-06-01
ibuprofen lysineNDA authorized generic2024-01-05
kabivenNew Drug Application2023-08-02
lip clear lysine plusOTC monograph final2023-02-06
lip clear lysine plus coldstickOTC monograph final2023-02-06
livdelziNew Drug Application2024-08-14
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent
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FDA Information
Ibuprofen Lysine, Neoprofen, Recordati Rare
84153372032-03-02DS, DP
ATC Codes
A: Alimentary tract and metabolism drugs
A12: Mineral supplements
A12A: Calcium supplements
A12AA: Calcium
A12AA09: Calcium citrate lysine complex
B: Blood and blood forming organ drugs
B05: Blood substitutes and perfusion solutions
B05X: I.v. solution additives
B05XB: Amino acids, i.v. solution additive
B05XB03: Lysine
V: Various drug classes in atc
V03: All other therapeutic products
V03A: All other therapeutic products
V03AF: Detoxifying agents for antineoplastic treatment
V03AF11: Arginine and lysine
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameLysine
INNlysine
Description
Lysine is a diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6. It has a role as a Daphnia magna metabolite. It is an alpha-amino acid, a diamino acid and a polar amino acid. It contains a 4-aminobutyl group. It is functionally related to a hexanoic acid. It is a conjugate base of a lysinium(1+). It is a conjugate acid of a lysinate.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NCCCC[C@H](N)C(=O)O
Identifiers
PDB
CAS-ID56-87-1
RxCUI
ChEMBL IDCHEMBL8085
ChEBI ID18019
PubChem CID866
DrugBankDB00123
UNII IDK3Z4F929H6 (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
ASIC1
ASIC1
GPRC6A
GPRC6A
AVPR1B
AVPR1B
OXTR
OXTR
SLC5A8
SLC5A8
NOS2
NOS2
PPARG
PPARG
AVPR1A
AVPR1A
AVPR2
AVPR2
Organism
Homo sapiens
Gene name
ASIC1
Gene synonyms
ACCN2, BNAC2
NCBI Gene ID
Protein name
acid-sensing ion channel 1
Protein synonyms
acid sensing (proton gated) ion channel 1, acid-sensing ion channel 1a protein, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, Cation channel, amiloride-sensitive, neuronal, 2
Uniprot ID
Mouse ortholog
Asic1 (11419)
acid-sensing ion channel 1 (Q6NXK8)
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Lysine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Aminosyn ii
Adverse Events
0 adverse events reported
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