Lysergide - PharmaKB

Lysergide

Lysergide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, and 5-hydroxytryptamine receptor 1A.

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Clinical Trials

62 clinical trials

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Indications Phases 4

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Mucopolysaccharidoses	D009083	—	E76.3	3	6	2	—	2	10
Mucopolysaccharidosis iv	D009085	—	E76.210	2	5	2	—	2	9
Syndrome	D013577	—	—	2	6	1	—	2	9
Anxiety disorders	D001008	EFO_0006788	F41.1	—	3	2	—	—	5
Osteochondrodysplasias	D010009	Orphanet_800	G71.13	—	—	1	—	1	2
Intracranial hypertension	D019586	EFO_1000992	—	—	—	1	—	—	1

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Lysosomal storage diseases	D016464	—	—	1	1	—	—	2	3
Major depressive disorder	D003865	EFO_0003761	F22	—	1	—	—	2	3
Depressive disorder	D003866	EFO_1002014	F32.A	—	1	—	—	2	3
Depression	D003863	—	F33.9	—	1	—	—	2	3
Mucopolysaccharidosis iii	D009084	—	E76.22	2	3	—	—	—	3
Headache	D006261	—	R51	—	2	—	—	—	2
Cluster headache	D003027	—	G44.00	—	2	—	—	—	2
Anxiety	D001007	EFO_0005230	F41.1	—	2	—	—	—	2
Alcoholism	D000437	EFO_0003829	F10.1	—	1	—	—	1	2
Cystinosis	D003554	—	E72.04	1	1	—	—	—	1

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	18	—	—	—	2	20
Fabry disease	D000795	Orphanet_324	E75.21	1	—	—	—	1	2

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Niemann-pick diseases	D009542	—	E75.24	—	—	—	—	2	2
Type a niemann-pick disease	D052536	EFO_1001380	E75.240	—	—	—	—	2	2
Frontotemporal dementia	D057180	—	G31.0	—	—	—	—	2	2
Type c niemann-pick disease	D052556	Orphanet_646	E75.242	—	—	—	—	2	2
Primary progressive aphasia	D018888	EFO_0009053	G31.01	—	—	—	—	2	2
Pick disease of the brain	D020774	EFO_0003096	G31.01	—	—	—	—	2	2
Personality disorders	D010554	—	F60.6	—	—	—	—	2	2
Dementia	D003704	EFO_0003862	F03	—	—	—	—	1	1
Cognition disorders	D003072	—	—	—	—	—	—	1	1
Neurocognitive disorders	D019965	—	F09	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Lysergide
INN	lysergide
Description	Lysergic acid diethylamide is an ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine. It has a role as a hallucinogen, a serotonergic agonist and a dopamine agonist. It is an ergoline alkaloid, an organic heterotetracyclic compound and a monocarboxylic acid amide. It is functionally related to a lysergamide.
Classification	Small molecule
Drug class	ergot alkaloid deriviatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1