Mulpleta, Mulpleo (previously lusutrombopag shionogi)(lusutrombopag)
Lusutrombopag, Mulpleo, Mulpleta (lusutrombopag) is a small molecule pharmaceutical. Lusutrombopag was first approved as Mulpleta on 2018-07-31. It is used to treat thrombocytopenia in the USA. It has been approved in Europe to treat thrombocytopenia. The pharmaceutical is active against thrombopoietin receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
Trade Name
FDA
EMA
Mulpleta
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mulpleta | New Drug Application | 2020-10-29 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| thrombocytopenia | HP_0001873 | D013921 | D69.6 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 4 | 1 | 1 | — | 6 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | 1 | 1 | — | 3 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | 3 | — | — | — | 3 |
| Thrombocytopenic purpura | D011696 | — | — | — | 1 | — | — | — | 1 |
| Purpura | D011693 | HP_0000979 | D69.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lusutrombopag |
| INN | lusutrombopag |
| Description | Lusutrombopag is a member of cinnamic acids. |
| Classification | Small molecule |
| Drug class | thrombopoetin agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC |
Identifiers
| PDB | — |
| CAS-ID | 1110766-97-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107831 |
| ChEBI ID | — |
| PubChem CID | 49843517 |
| DrugBank | DB13125 |
| UNII ID | 6LL5JFU42F (ChemIDplus, GSRS) |
Target
Agency Approved
MPL
MPL
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 198 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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33 adverse events reported
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