Luspatercept
Reblozyl (luspatercept) is a protein pharmaceutical. Luspatercept was first approved as Reblozyl on 2019-11-08. It is used to treat anemia in the USA. It has been approved in Europe to treat anemia, beta-thalassemia, and myelodysplastic syndromes. It is known to target growth/differentiation factor 11, bone morphogenetic protein 10, growth/differentiation factor 2, growth/differentiation factor 8, and bone morphogenetic protein 6.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Reblozyl
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anemia | EFO_0004272 | D000740 | D64.9 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
luspatercept, Reblozyl, Celgene Corporation, a Bristol-Myers Squibb Company | |||
| 2030-08-28 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0896 | Injection, luspatercept-aamt, 0.25 mg |
Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 8 | 6 | 1 | 2 | 18 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | 6 | 1 | 1 | — | 9 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | 3 | 2 | 1 | 1 | 7 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary myelofibrosis | D055728 | — | D47.4 | — | 1 | 1 | — | — | 2 |
| Erythrocyte transfusion | D017707 | — | — | — | — | 1 | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thalassemia | D013789 | EFO_1001996 | D56 | — | 1 | — | — | — | 1 |
| Alpha-thalassemia | D017085 | Orphanet_846 | D56.0 | — | 1 | — | — | — | 1 |
| Thrombocytosis | D013922 | HP_0001894 | D75.83 | — | 1 | — | — | — | 1 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Luspatercept |
| INN | luspatercept |
| Description | Luspatercept |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: transforming growth factor receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1373715-00-4 |
| RxCUI | 2262544 |
| ChEMBL ID | CHEMBL3039545 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12281 |
| UNII ID | AQK7UBA1LS (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GDF11
GDF11
BMP10
BMP10
GDF2
GDF2
MSTN
MSTN
BMP6
BMP6
Variants
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Financial
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Reblozyl – Bristol Myers Squibb
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Reblozyl – Merck Sharp & Dohme
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 578 documents
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Safety
Black-box Warning
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Adverse Events
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286 adverse events reported
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