Lumiracoxib
Lumiracoxib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin G/H synthase 2.
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Clinical Trials
17 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | 9 | 2 | — | 11 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 2 | — | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 2 | — | 2 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | 1 | 1 | — | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
| Controlled hypotension | D007023 | — | — | — | — | — | 1 | — | 1 |
| Musculoskeletal pain | D059352 | — | — | — | — | — | 1 | — | 1 |
| Gouty arthritis | D015210 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | 5 | — | — | 5 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | 1 | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lumiracoxib |
| INN | lumiracoxib |
| Description | Lumiracoxib is an amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is an organofluorine compound, an organochlorine compound, an amino acid, a secondary amino compound and a monocarboxylic acid. |
| Classification | Small molecule |
| Drug class | cyclooxygenase-2 inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(Nc2c(F)cccc2Cl)c(CC(=O)O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 220991-20-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL404108 |
| ChEBI ID | 73044 |
| PubChem CID | 151166 |
| DrugBank | DB01283 |
| UNII ID | V91T9204HU (ChemIDplus, GSRS) |
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Safety
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54 adverse events reported
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