Lucitanib
Lucitanib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target platelet-derived growth factor receptor alpha, proto-oncogene tyrosine-protein kinase receptor Ret, mast/stem cell growth factor receptor Kit, vascular endothelial growth factor receptor 1, platelet-derived growth factor receptor beta, vascular endothelial growth factor receptor 2, and fibroblast growth factor receptor 1.
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Events Timeline
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 1 | 4 | — | — | 4 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | — | 1 | 4 | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 3 | 1 | — | — | 3 |
| Duodenal ulcer | D004381 | EFO_0004607 | K26 | — | 2 | 2 | — | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 2 | 2 | — | — | 2 |
| Small cell lung carcinoma | D055752 | — | — | — | 2 | 1 | — | — | 2 |
| Heartburn | D006356 | — | R12 | — | — | 2 | — | — | 2 |
| Stomach ulcer | D013276 | — | K25 | — | 1 | 1 | — | — | 1 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 5 | 4 | — | — | — | 6 |
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Female genital neoplasms | D005833 | — | — | 1 | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 1 | — | — | — | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lucitanib |
| INN | lucitanib |
| Description | E-3810 free base is a naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine. It has a role as an antineoplastic agent, a fibroblast growth factor receptor antagonist and a vascular endothelial growth factor receptor antagonist. It is a member of quinolines, an aromatic ether, a member of cyclopropanes, a primary amino compound and a naphthalenecarboxamide. It is a conjugate base of an E-3810(1+). |
| Classification | Small molecule |
| Drug class | angiogenesis inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12 |
Identifiers
| PDB | — |
| CAS-ID | 1058137-23-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2220486 |
| ChEBI ID | 65209 |
| PubChem CID | 25031915 |
| DrugBank | — |
| UNII ID | PP449XA4BH (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RET
RET
Organism
Homo sapiens
Gene name
RET
Gene synonyms
CDHF12, CDHR16, PTC, RET51
NCBI Gene ID
Protein name
proto-oncogene tyrosine-protein kinase receptor Ret
Protein synonyms
Cadherin family member 12, cadherin-related family member 16, Proto-oncogene c-Ret, rearranged during transfection, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), RET receptor tyrosine kinase
Uniprot ID
Mouse ortholog
Ret (19713)
proto-oncogene tyrosine-protein kinase receptor Ret (P35546)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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25 adverse events reported
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