Loxoprofen
Loxoprofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
18 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 1 | — | — | 1 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Loxoprofen |
| INN | loxoprofen |
| Description | Loxoprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a prodrug. It is a monocarboxylic acid and a member of cyclopentanones. It is functionally related to a propionic acid. It is a conjugate acid of a loxoprofen(1-). |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 68767-14-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19299 |
| ChEBI ID | 76172 |
| PubChem CID | 3965 |
| DrugBank | DB09212 |
| UNII ID | 3583H0GZAP (ChemIDplus, GSRS) |
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Safety
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2,155 adverse events reported
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