Loxoprofen
Loxoprofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | 1 | — | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 1 | 1 | 2 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | 1 | — | 1 |
| Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
| Spondylitis | D013166 | — | M46.9 | — | — | — | 1 | — | 1 |
| Hemorrhoids | D006484 | EFO_0009552 | K64 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | — | M54.5 | — | 1 | 1 | — | 2 | 4 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 2 | — | 1 | 3 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | 1 | — | 1 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 1 | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | — | — | 1 |
| Fever | D005334 | — | R50.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Back pain | D001416 | — | M54 | — | 1 | — | — | 2 | 3 |
| Myalgia | D063806 | — | M79.1 | 1 | 1 | — | — | — | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 1 | — | — | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
| Neck pain | D019547 | — | M54.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary neoplasms | D010911 | — | — | — | — | — | — | 1 | 1 |
| Adenoma | D000236 | — | — | — | — | — | — | 1 | 1 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | — | 1 | 1 |
| Sciatica | D012585 | — | M54.3 | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Acute pain | D059787 | — | R52 | — | — | — | — | 1 | 1 |
| Chronic pain | D059350 | — | — | — | — | — | — | 1 | 1 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | — | — | — | 1 | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Loxoprofen |
| INN | loxoprofen |
| Description | Loxoprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a prodrug. It is a monocarboxylic acid and a member of cyclopentanones. It is functionally related to a propionic acid. It is a conjugate acid of a loxoprofen(1-). |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 68767-14-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19299 |
| ChEBI ID | 76172 |
| PubChem CID | 3965 |
| DrugBank | DB09212 |
| UNII ID | 3583H0GZAP (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,273 adverse events reported
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