Lovastatin
Altoprev, Lovastatin (lovastatin) is a small molecule pharmaceutical. Lovastatin was first approved as Mevacor on 1987-08-31. It is used to treat coronary artery disease, hypercholesterolemia, hyperlipoproteinemias, and hypertriglyceridemia in the USA. The pharmaceutical is active against 3-hydroxy-3-methylglutaryl-Coenzyme A reductase. In addition, it is known to target nuclear receptor subfamily 1 group I member 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Lovastatin (discontinued: Altoprev, Lovastatin, Mevacor)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lovastatin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALTOPREV | Covis Pharma | N-021316 DISCN | 2002-06-26 | 4 products, RLD |
| MEVACOR | Merck & Co | N-019643 DISCN | 1987-08-31 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| advicor | New Drug Application | 2012-10-04 |
| altoprev | New Drug Application | 2024-12-31 |
| lovastatin | ANDA | 2025-08-26 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypercholesterolemia | — | D006937 | — |
| coronary artery disease | — | D003324 | I25.1 |
| hypertriglyceridemia | EFO_0004211 | D015228 | — |
| hyperlipoproteinemias | — | D006951 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C10: Lipid modifying agents
— C10A: Lipid modifying agents, plain
— C10AA: Hmg coa reductase inhibitors, plain lipid modifying drugs
— C10AA02: Lovastatin
— C10B: Lipid modifying agents, combinations
— C10BA: Combinations of various lipid modifying agents
— C10BA01: Lovastatin and nicotinic acid
HCPCS
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Clinical
Clinical Trials
622 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypercholesterolemia | D006937 | — | — | 4 | 5 | 58 | 27 | 21 | 115 |
| Dyslipidemias | D050171 | — | — | 4 | 3 | 25 | 10 | 7 | 49 |
| Healthy volunteers/patients | — | — | — | 33 | 1 | — | 4 | 3 | 41 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 15 | 11 | 11 | 39 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 10 | 1 | 10 | 9 | 5 | 35 |
| Coronary disease | D003327 | — | — | — | 1 | 15 | 12 | 4 | 32 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 4 | 10 | 9 | 7 | 31 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | 1 | 1 | 15 | 8 | 6 | 30 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | 3 | 8 | 10 | 8 | 29 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | 1 | 9 | 12 | 6 | 28 |
Show 105 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 2 | 4 | 3 | — | 1 | 7 |
| Colorectal neoplasms | D015179 | — | — | — | 4 | 1 | — | — | 5 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | 4 | — | — | 5 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 1 | — | — | 5 |
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | 1 | 1 | — | 3 | 5 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 2 | 3 | 2 | — | 1 | 5 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 1 | 2 | — | — | 4 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 2 | 2 | — | — | 4 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 3 | 4 | 1 | — | — | 4 |
| Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | — | 4 | — | — | 4 |
Show 46 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 11 | — | — | — | 13 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 4 | — | — | 3 | 8 |
| Neoplasms | D009369 | — | C80 | 5 | 2 | — | — | 2 | 8 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 4 | — | — | 1 | 6 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 4 | — | — | 1 | 6 |
| Lung neoplasms | D008175 | — | C34.90 | — | 5 | — | — | — | 5 |
| Small cell lung carcinoma | D055752 | — | — | — | 4 | — | — | — | 4 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 3 | — | — | — | 4 |
| Neurofibromatosis 1 | D009456 | — | Q85.01 | 1 | 2 | — | — | 1 | 4 |
| Neurofibromatoses | D017253 | — | Q85.00 | 1 | 2 | — | — | 1 | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
| Acute kidney injury | D058186 | — | N17 | 1 | — | — | — | 2 | 3 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Neurotoxicity syndromes | D020258 | — | G92 | 1 | — | — | — | — | 1 |
| Lipodystrophy | D008060 | — | E88.1 | 1 | — | — | — | — | 1 |
| Hiv seronegativity | D018023 | — | — | 1 | — | — | — | — | 1 |
| Hepatitis b | D006509 | — | — | 1 | — | — | — | — | 1 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Show 27 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myalgia | D063806 | — | M79.1 | — | — | — | — | 2 | 2 |
| Congenital heart defects | D006330 | — | Q24.9 | — | — | — | — | 2 | 2 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 2 | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 2 | 2 |
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 1 | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 1 | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 1 | 1 |
| Cytokinesis | D048749 | — | — | — | — | — | — | 1 | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | — | — | — | 1 | 1 |
| Anaplastic thyroid carcinoma | D065646 | — | — | — | — | — | — | 1 | 1 |
Show 25 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lovastatin |
| INN | lovastatin |
| Description | Lovastatin is a fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). It has a role as an Aspergillus metabolite, a prodrug, an anticholesteremic drug and an antineoplastic agent. It is a polyketide, a statin (naturally occurring), a member of hexahydronaphthalenes, a delta-lactone and a fatty acid ester. It is functionally related to a (S)-2-methylbutyric acid and a mevastatin. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 75330-75-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL503 |
| ChEBI ID | 40303 |
| PubChem CID | 53232 |
| DrugBank | DB00227 |
| UNII ID | 9LHU78OQFD (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ITGAL
ITGAL
Organism
Homo sapiens
Gene name
ITGAL
Gene synonyms
CD11A
NCBI Gene ID
Protein name
integrin alpha-L
Protein synonyms
antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, CD11 antigen-like family member A, CD11a, integrin gene promoter, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA-1 alpha, LFA-1A, lymphocyte function-associated antigen 1, alpha polypeptide
Uniprot ID
Mouse ortholog
Itgal (16408)
integrin alpha-L (Q3U159)
Variants
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Financial
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Estimated US medical usage
Lovastatin
Total medical expenditures per year (USD, in millions)
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Lovastatin
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Niacin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,825 adverse events reported
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