Losmapimod
Losmapimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase 14.
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Commercial
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 2 | 1 | 1 | — | — | 4 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | 5 | — | — | — | 7 |
| Obstructive lung diseases | D008173 | — | — | 1 | 5 | — | — | — | 6 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | 5 | — | — | — | 5 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 2 | 1 | — | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 2 | — | — | — | 3 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 2 | — | — | — | 2 |
| Depression | D003863 | — | F33.9 | — | 2 | — | — | — | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 2 | — | — | — | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 2 | — | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Losmapimod |
| INN | losmapimod |
| Description | 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine. |
| Classification | Small molecule |
| Drug class | immunomodulators: mitogen-activated protein (MAP) kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 585543-15-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1088752 |
| ChEBI ID | — |
| PubChem CID | 11552706 |
| DrugBank | DB12270 |
| UNII ID | F2DQF16BXE (ChemIDplus, GSRS) |
Target
Agency Approved
MAPK14
MAPK14
Organism
Homo sapiens
Gene name
MAPK14
Gene synonyms
CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
NCBI Gene ID
Protein name
mitogen-activated protein kinase 14
Protein synonyms
CSAID-binding protein, CSBP, cytokine suppressive anti-inflammatory drug binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, SAPK2a, Stress-activated protein kinase 2a
Uniprot ID
Mouse ortholog
Mapk14 (26416)
mitogen-activated protein kinase 14 (P47811)
Alternate
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Variants
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Financial
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Trends
PubMed Central
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Safety
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Adverse Events
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