PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsLosartan
Losartan
Arbli, Cozaar, Hyzaar, Losartan Potassium (losartan) is a small molecule pharmaceutical. Losartan was first approved as Cozaar on 1995-04-14. It is used to treat diabetic nephropathies, heart failure, hypertension, left ventricular dysfunction, and left ventricular hypertrophy in the USA. The pharmaceutical is active against type-1 angiotensin II receptor.
Download report
Favorite
COVID-19
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
arbliNew Drug Application2025-03-20
cozaarNew Drug Application2025-06-20
hyzaarNew Drug Application2025-10-02
losartanANDA2018-02-15
losartan pot/hctzANDA2019-08-02
losartan potassiumANDA2025-10-03
losartan potassium and hydrochlorothiazideANDA2025-09-04
losartan potassium and hydrochlorothiazideANDA2025-10-02
losartan potassium and hydrochlorothiazide losartan potassium hctzANDA2019-10-14
losartan potassium losartan potassiumANDA2025-07-28
Show 9 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09CA01: Losartan
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DA01: Losartan and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DB06: Losartan and amlodipine
HCPCS
No data
Clinical
Clinical Trials
445 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameLosartan
INNlosartan
Description
Losartan is a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an endothelin receptor antagonist and an anti-arrhythmia drug. It is a biphenylyltetrazole and a member of imidazoles. It is a conjugate acid of a losartan(1-).
Classification
Small molecule
Drug classangiotensin II receptor antagonists
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
Identifiers
PDB—
CAS-ID114798-26-4
RxCUI—
ChEMBL IDCHEMBL191
ChEBI ID6541
PubChem CID3961
DrugBankDB00678
UNII IDJMS50MPO89 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP2C9
CYP2C9
Organism
Homo sapiens
Gene name
CYP2C9
Gene synonyms
CYP2C10
NCBI Gene ID
1559
Protein name
cytochrome P450 2C9
Protein synonyms
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, Cholesterol 25-hydroxylase, CYPIIC9, cytochrome P-450 S-mephenytoin 4-hydroxylase, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, cytochrome P450, family 2, subfamily C, polypeptide 9, flavoprotein-linked monooxygenase, microsomal monooxygenase, S-mephenytoin 4-hydroxylase, xenobiotic monooxygenase
Uniprot ID
Q8WW80
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Losartan
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Losartan
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 29,998 documents
View more details
Safety
Black-box Warning
Black-box warning for: Arbli, Cozaar, Hyzaar, Losartan, Losartan potassium, Losartan potassium and hydrochlorothiazide, Losartan potassium and hydrochlorothiazide, Losartan potassium and hydrochlorothiazide losartan potassium hctz, Losartan potassium losartan potassium, Losartan potassium losortan potassium, Losartan potassium tablets, 100 mg, Losartan potassium tablets, 100 mg losartan potassium tablets, 25 mg losartan potassium tablets, 50 mg, Losartan potassium tablets, 25 mg, Losartan potassium tablets, 50 mg, Losartan potatssium, Losatan potassium, Losortan potassium, Tradename
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
141,752 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use