PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsLoperamide
Loperamide
Imodium, Loperamide (loperamide) is a small molecule pharmaceutical. Loperamide was first approved as Imodium on 1982-01-01. It is used to treat bacillary dysentery, diarrhea, and functional colonic diseases in the USA. The pharmaceutical is active against mu-type opioid receptor.
Download report
Favorite
Top OTC Drugs
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Imodium, Loperamide (discontinued: Imodium, Loperamide)
Combinations
Imodium multi-symptom, Loperamide simethicone (discontinued: Imodium multi-symptom, Loperamide simethicone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Loperamide hydrochloride
Tradename
Company
Number
Date
Products
LOPERAMIDE HYDROCHLORIDEBionPharmaN-021855 OTC2005-08-04
2 products, RLD, RS
IMODIUM A-DJohnson & JohnsonN-019487 OTC1988-03-01
2 products, RLD, RS
IMODIUM A-DJohnson & JohnsonN-019860 OTC1989-11-22
1 products, RLD, RS
Show 4 discontinued
Loperamide hydrochloride
+
Simethicone
Tradename
Company
Number
Date
Products
IMODIUM MULTI-SYMPTOM RELIEFJohnson & JohnsonN-021140 OTC2000-11-30
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amazon basic care loperamide hydrochlorideANDA2024-05-15
anti diarrhealANDA2025-04-08
anti diarrheal and anti gasANDA2024-07-22
anti diarrheal anti gasANDA2024-07-23
anti diarrheal plus anti gasANDA2024-07-11
anti-diarrhealNew Drug Application2025-04-07
anti-diarrheal 24/7 for life by 7-elevenANDA2023-12-12
anti-diarrheal, caseys 4good anti-diarrheal, cvp healthANDA2024-12-29
anti-diarrheal, circle kANDA2024-12-29
anti-diarrheal/anti-gasANDA2025-02-27
Show 53 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diarrhea—D003967R19.7
bacillary dysentery—D004405A03
functional colonic diseases—D003109—
flatulence—D005414R14.3
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA03: Loperamide
— A07DA05: Loperamide oxide
— A07DA53: Loperamide, combinations
HCPCS
No data
Clinical
Clinical Trials
104 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Irritable bowel syndromeD043183EFO_0000555K58———1—1
DiarrheaD003967—R19.7———1—1
SyndromeD013577—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameLoperamide
INNloperamide
Description
Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It is a member of piperidines, a monocarboxylic acid amide, a member of monochlorobenzenes and a tertiary alcohol. It is a conjugate base of a loperamide(1+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
Identifiers
PDB—
CAS-ID53179-11-6
RxCUI—
ChEMBL IDCHEMBL841
ChEBI ID6532
PubChem CID3955
DrugBankDB00836
UNII ID6X9OC3H4II (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (Q9R1M0)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Loperamide
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Loperamide
+
Simethicone
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 8,810 documents
View more details
Safety
Black-box Warning
Black-box warning for: Loperamide hydrochloride
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
24,510 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use