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Drug ReportsLoperamide
Loperamide
Imodium, Loperamide (loperamide) is a small molecule pharmaceutical. Loperamide was first approved as Imodium on 1982-01-01. It is used to treat bacillary dysentery, diarrhea, and functional colonic diseases in the USA. The pharmaceutical is active against mu-type opioid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Imodium, Loperamide (discontinued: Imodium, Loperamide)
Combinations
Imodium multi-symptom, Loperamide simethicone (discontinued: Imodium multi-symptom, Loperamide simethicone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Loperamide hydrochloride
Tradename
Company
Number
Date
Products
LOPERAMIDE HYDROCHLORIDEBionPharmaN-021855 OTC2005-08-04
2 products, RLD, RS
IMODIUM A-DJohnson & JohnsonN-019487 OTC1988-03-01
2 products, RLD, RS
IMODIUM A-DJohnson & JohnsonN-019860 OTC1989-11-22
1 products, RLD, RS
Show 4 discontinued
Loperamide hydrochloride
+
Simethicone
Tradename
Company
Number
Date
Products
IMODIUM MULTI-SYMPTOM RELIEFJohnson & JohnsonN-021140 OTC2000-11-30
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amazon basic care loperamide hydrochlorideANDA2024-05-15
anti diarrhealANDA2025-01-03
anti diarrheal and anti gasANDA2024-07-22
anti diarrheal anti gasANDA2024-07-23
anti diarrheal plus anti gasANDA2024-07-11
anti-diarrhealANDA2025-01-06
anti-diarrheal 24/7 for life by 7-elevenANDA2023-12-12
anti-diarrheal, caseys 4good anti-diarrheal, cvp healthANDA2024-12-29
anti-diarrheal, circle kANDA2024-12-29
anti-diarrheal/anti-gas multi-symptom reliefANDA2022-07-12
Show 54 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diarrheaHP_0002014D003967R19.7
bacillary dysentery—D004405A03
functional colonic diseases—D003109—
flatulence—D005414R14.3
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA03: Loperamide
— A07DA05: Loperamide oxide
— A07DA53: Loperamide, combinations
HCPCS
No data
Clinical
Clinical Trials
101 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Irritable bowel syndromeD043183EFO_0000555K58———1—1
DiarrheaD003967HP_0002014R19.7———1—1
SyndromeD013577—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLoperamide
INNloperamide
Description
Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It is a member of piperidines, a monocarboxylic acid amide, a member of monochlorobenzenes and a tertiary alcohol. It is a conjugate base of a loperamide(1+).
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
Identifiers
PDB—
CAS-ID53179-11-6
RxCUI—
ChEMBL IDCHEMBL841
ChEBI ID6532
PubChem CID3955
DrugBankDB00836
UNII ID6X9OC3H4II (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (Q9R1M0)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Loperamide
Total medical expenditures per year (USD, in millions)
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Loperamide
+
Simethicone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,561 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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24,056 adverse events reported
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