Loperamide
Imodium, Loperamide (loperamide) is a small molecule pharmaceutical. Loperamide was first approved as Imodium on 1982-01-01. It is used to treat bacillary dysentery, diarrhea, and functional colonic diseases in the USA. The pharmaceutical is active against mu-type opioid receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Imodium, Loperamide (discontinued: Imodium, Loperamide)
CombinationsImodium multi-symptom, Loperamide simethicone (discontinued: Imodium multi-symptom, Loperamide simethicone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Loperamide hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOPERAMIDE HYDROCHLORIDE | BionPharma | N-021855 OTC | 2005-08-04 | 2 products, RLD, RS |
| IMODIUM A-D | Johnson & Johnson | N-019487 OTC | 1988-03-01 | 2 products, RLD, RS |
| IMODIUM A-D | Johnson & Johnson | N-019860 OTC | 1989-11-22 | 1 products, RLD, RS |
Show 4 discontinued
Loperamide hydrochloride
+
Simethicone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| IMODIUM MULTI-SYMPTOM RELIEF | Johnson & Johnson | N-021140 OTC | 2000-11-30 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| amazon basic care loperamide hydrochloride | ANDA | 2024-05-15 |
| anti diarrheal | ANDA | 2024-06-25 |
| anti diarrheal and anti gas | ANDA | 2024-07-22 |
| anti diarrheal anti gas | ANDA | 2024-07-23 |
| anti diarrheal plus anti gas | ANDA | 2024-07-11 |
| anti-diarrheal | ANDA | 2024-10-22 |
| anti-diarrheal 24/7 for life by 7-eleven | ANDA | 2023-12-12 |
| anti-diarrheal, caseys 4good anti-diarrheal, cvp health | ANDA | 2023-08-31 |
| anti-diarrheal, circle k | ANDA | 2022-10-12 |
| anti-diarrheal/anti-gas multi-symptom relief | ANDA | 2022-07-12 |
Show 56 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| diarrhea | HP_0002014 | D003967 | R19.7 |
| bacillary dysentery | — | D004405 | A03 |
| functional colonic diseases | — | D003109 | — |
| flatulence | — | D005414 | R14.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
100 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diarrhea | D003967 | HP_0002014 | R19.7 | 2 | 8 | 8 | 7 | 4 | 26 |
| Syndrome | D013577 | — | — | 1 | — | 2 | 1 | 7 | 11 |
| Fecal incontinence | D005242 | — | R15 | — | 1 | 2 | 1 | 3 | 6 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | 1 | 1 | 4 | 6 |
| Clostridium infections | D003015 | EFO_1000874 | A05.2 | 1 | 3 | 1 | 1 | — | 4 |
| Dysentery | D004403 | EFO_1001869 | — | — | — | — | 1 | 1 | 2 |
| Colitis | D003092 | EFO_0003872 | K52.9 | 1 | — | — | 1 | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | 1 | — | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | 1 | — | 1 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | — | — | — | 1 | — | 1 |
Show 1 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 12 | 1 | — | 2 | 17 |
| Neoplasms | D009369 | — | C80 | 1 | 4 | 2 | — | 1 | 7 |
| Colorectal neoplasms | D015179 | — | — | — | 3 | 1 | — | — | 4 |
| Rectal neoplasms | D012004 | — | — | 1 | — | 1 | — | 2 | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | 1 | — | — | 3 |
| Short bowel syndrome | D012778 | — | K90.82 | — | — | 3 | — | — | 3 |
| Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 2 | 1 | — | — | 2 |
| Virus diseases | D014777 | — | B34 | — | 2 | 1 | — | — | 2 |
| Infections | D007239 | EFO_0000544 | — | — | 2 | 1 | — | — | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | 1 | 4 |
| Sarcoma | D012509 | — | — | — | 2 | — | — | — | 2 |
| Alveolar soft part sarcoma | D018234 | — | — | — | 2 | — | — | — | 2 |
| Gliosarcoma | D018316 | — | — | 1 | 1 | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 1 | — | — | — | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 1 | — | — | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | 1 | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 1 |
Show 16 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | 2 | 9 |
| Low anterior resection syndrome | D000094123 | — | — | 1 | — | — | — | 4 | 5 |
| Intestinal obstruction | D007415 | — | K56.60 | 2 | — | — | — | — | 2 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
| Uterine neoplasms | D014594 | EFO_0003859 | C55 | 1 | — | — | — | — | 1 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fever | D005334 | HP_0001945 | R50.9 | — | — | — | — | 1 | 1 |
| Hyperthermia | D000084462 | — | — | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | — | — | — | 1 | 1 |
| Digestive system neoplasms | D004067 | — | — | — | — | — | — | 1 | 1 |
| Gastrointestinal transit | D005772 | — | — | — | — | — | — | 1 | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | — | — | — | 1 | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Loperamide |
| INN | loperamide |
| Description | Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It is a member of piperidines, a monocarboxylic acid amide, a member of monochlorobenzenes and a tertiary alcohol. It is a conjugate base of a loperamide(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 53179-11-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL841 |
| ChEBI ID | 6532 |
| PubChem CID | 3955 |
| DrugBank | DB00836 |
| UNII ID | 6X9OC3H4II (ChemIDplus, GSRS) |
Target
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Loperamide
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Loperamide
+
Simethicone
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 8,388 documents
View more details
Safety
Black-box Warning
Black-box warning for: Loperamide hydrochloride
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
22,966 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use