Lomustine
Gleostine (lomustine) is a small molecule pharmaceutical. Lomustine was first approved as Gleostine on 1982-01-01. It is used to treat brain neoplasms, colonic neoplasms, hodgkin disease, kidney neoplasms, and lung neoplasms amongst others in the USA.
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142 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | — | 8 | — | 1 | 1 | 10 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | 1 | 1 | 3 | 5 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 4 | — | 1 | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 1 | — | 1 | — | 2 |
| Virus diseases | D014777 | — | B34 | — | — | — | 1 | — | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | 1 | — | 1 |
| B-cell lymphoma | D016393 | — | — | — | — | — | 1 | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 12 | 30 | 20 | — | 5 | 58 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 6 | 8 | 10 | — | 1 | 23 |
| Central nervous system neoplasms | D016543 | — | — | 2 | 7 | 11 | — | 3 | 22 |
| Recurrence | D012008 | — | — | 4 | 9 | 8 | — | 3 | 18 |
| Glioma | D005910 | EFO_0000520 | — | 4 | 5 | 8 | — | 1 | 17 |
| Astrocytoma | D001254 | EFO_0000271 | — | 3 | 5 | 9 | — | 1 | 17 |
| Nervous system neoplasms | D009423 | — | — | — | 6 | 9 | — | 2 | 16 |
| Leukemia | D007938 | — | C95 | — | 6 | 7 | — | 4 | 15 |
| Medulloblastoma | D008527 | — | — | 3 | 7 | 5 | — | 2 | 15 |
| Neoplasms | D009369 | — | C80 | 2 | 6 | 3 | — | 1 | 10 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | 2 | — | — | 2 | 4 |
| Lung neoplasms | D008175 | — | C34.90 | — | 2 | — | — | 1 | 3 |
| Ependymoma | D004806 | — | — | 1 | 1 | — | — | 1 | 3 |
| Melanoma | D008545 | — | — | 2 | 1 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | — | — | — | 2 |
| Hodgkin disease | D006689 | — | C81 | — | 2 | — | — | — | 2 |
| Primitive neuroectodermal tumors | D018242 | — | — | — | 1 | — | — | 1 | 2 |
| Neuroectodermal tumors | D017599 | — | — | — | 1 | — | — | 1 | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
Show 26 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 2 | — | — | — | 1 | 3 |
| Meningeal carcinomatosis | D055756 | EFO_1001012 | — | 1 | — | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoid leukemia | D007945 | — | C91 | — | — | — | — | 2 | 2 |
| Acute disease | D000208 | — | — | — | — | — | — | 1 | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | — | — | — | — | 1 | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 1 | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 1 | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | — | 1 | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | — | — | — | 1 | 1 |
| Classical conditioning | D003214 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lomustine |
| INN | lomustine |
| Description | Lomustine is an N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours. It has a role as an alkylating agent and an antineoplastic agent. It is a member of N-nitrosoureas and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | antineoplastics (chloroethylamine derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=NN(CCCl)C(=O)NC1CCCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 13010-47-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL514 |
| ChEBI ID | 6520 |
| PubChem CID | 3950 |
| DrugBank | DB01206 |
| UNII ID | 7BRF0Z81KG (ChemIDplus, GSRS) |
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Lomustine
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Additional graphs summarizing 10,111 documents
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Safety
Black-box Warning
Black-box warning for: Gleostine
Adverse Events
Top Adverse Reactions
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1,906 adverse events reported
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