Lobeline - PharmaKB

Lobeline

Lobeline is a small molecule pharmaceutical. It is currently being investigated in clinical studies.

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Clinical

Clinical Trials

96 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Tobacco use cessation	D020340	—	—	—	1	—	1	11	13
Cigarette smoking	D000073865	—	—	—	—	—	2	4	6

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Tobacco use disorder	D014029	—	F17	4	10	2	—	7	20
Tobacco use	D064424	—	Z72.0	—	3	2	—	13	17
Addictive behavior	D016739	EFO_0004347	—	—	—	1	—	1	2

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Smoking	D012907	EFO_0004318	—	3	2	—	—	7	12
Smoking cessation	D016540	EFO_0004319	—	4	1	—	—	3	7
Harm reduction	D040261	—	—	3	1	—	—	—	4
Knee osteoarthritis	D020370	EFO_0004616	M17	1	1	—	—	1	2
Osteoarthritis	D010003	EFO_0002506	M15-M19	1	1	—	—	1	2
Attention deficit disorder with hyperactivity	D001289	EFO_0003888	F90	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Marijuana abuse	D002189	EFO_0007191	F12	1	—	—	—	—	1
Healthy volunteers/patients	—	—	—	1	—	—	—	—	1
Amphetamine-related disorders	D019969	EFO_0004701	F15	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Tobacco smoking	D000073869	—	—	—	—	—	—	3	3
Cardiovascular diseases	D002318	EFO_0000319	I98	—	—	—	—	2	2
Type 2 diabetes mellitus	D003924	EFO_0001360	E11	—	—	—	—	2	2
Blood pressure	D001794	EFO_0004325	—	—	—	—	—	2	2
Obesity	D009765	EFO_0001073	E66.9	—	—	—	—	2	2
Insulin resistance	D007333	EFO_0002614	E88.819	—	—	—	—	1	1
Hunger	D006815	—	—	—	—	—	—	1	1
Metabolism	D008660	GO_0008152	—	—	—	—	—	1	1
Essential hypertension	D000075222	—	I10	—	—	—	—	1	1
Cerebral infarction	D002544	—	I63	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Lobeline
INN	lobeline
Description	(-)-lobeline is an optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position. It has a role as a nicotinic acetylcholine receptor agonist. It is a piperidine alkaloid, a tertiary amine and an aromatic ketone.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1