Lixivaptan
Lixivaptan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vasopressin V2 receptor.
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Commercial
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyponatremia | D007010 | — | E87.1 | — | — | 4 | — | 1 | 5 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lixivaptan |
| INN | lixivaptan |
| Description | Lixivaptan (VPA-985) is an orally-active, non-peptide, selective vasopressin 2 receptor antagonist being developed as an investigational drug by Palladio Biosciences, Inc. (Palladio), a subsidiary of Centessa Pharmaceuticals plc. As of December 2021, lixivaptan is in Phase III clinical development for the treatment of Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease. The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to lixivaptan for the treatment of ADPKD.
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| Classification | Small molecule |
| Drug class | aptamers, classical and mirror; vasopressin receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 |
Identifiers
| PDB | — |
| CAS-ID | 168079-32-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL49429 |
| ChEBI ID | — |
| PubChem CID | 172997 |
| DrugBank | — |
| UNII ID | 8F5X4B082E (ChemIDplus, GSRS) |
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Lixivaptan – Centessa Pharmaceuticals
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Additional graphs summarizing 264 documents
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Safety
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Adverse Events
0 adverse events reported
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