Lithium
Lithium, Lithobid (lithium) is a small molecule pharmaceutical. Lithium was first approved as Lithobid on 1982-01-01. It is used to treat bipolar disorder, conduct disorder, depressive disorder, and post-traumatic stress disorders in the USA. The pharmaceutical is active against inositol monophosphatase 1. In addition, it is known to target glycogen synthase kinase-3 beta.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Lithium, Lithobid (discontinued: Eskalith, Lithane, Lithium, Lithonate, Lithotabs)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lithium carbonate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LITHOBID | ANI Pharmaceuticals | N-018027 RX | 1982-01-01 | 1 products, RLD, RS |
| LITHIUM CARBONATE | Hikma Pharmaceuticals | N-017812 RX | 1982-01-01 | 3 products, RLD |
| LITHIUM CARBONATE | Hikma Pharmaceuticals | N-018558 RX | 1982-01-29 | 1 products, RLD, RS |
Show 7 discontinued
Lithium citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LITHIUM CITRATE | Hikma Pharmaceuticals | N-018421 DISCN | 1982-01-01 | 1 products, RLD |
| LITHONATE | Solvay Pharmaceuticals | N-017672 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lithane | 2006-06-12 | |
| lithium | ANDA | 2024-11-05 |
| lithium carbonate | New Drug Application | 2024-10-09 |
| lithium carbonate extended release | 2007-03-30 | |
| lithium carbonate lithium carbonate | ANDA | 2022-11-24 |
| lithium lithium carbonate | New Drug Application | 2022-11-22 |
| lithobid | New Drug Application | 2022-10-28 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
LITHIUM CITRATE, LITHIUM CITRATE, RUBICON | |||
| 2024-03-18 | CGT | ||
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX04: Lithium succinate
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AN: Lithium antipsychotics
— N05AN01: Lithium
HCPCS
Code | Description |
|---|---|
| A4235 | Replacement battery, lithium, for use with medically necessary home blood glucose monitor owned by patient, each |
| A4601 | Lithium ion battery, rechargeable, for non-prosthetic use, replacement |
| A4602 | Replacement battery for external infusion pump owned by patient, lithium, 1.5 volt, each |
| E2397 | Power wheelchair accessory, lithium-based battery, each |
| K0604 | Replacement battery for external infusion pump owned by patient, lithium, 3.6 volt, each |
| K0605 | Replacement battery for external infusion pump owned by patient, lithium, 4.5 volt, each |
| L7367 | Lithium ion battery, rechargeable, replacement |
| L7368 | Lithium ion battery charger, replacement only |
| L8623 | Lithium ion battery for use with cochlear implant device speech processor, other than ear level, replacement, each |
| L8624 | Lithium ion battery for use with cochlear implant or auditory osseointegrated device speech processor, ear level, replacement, each |
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Clinical
Clinical Trials
415 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 7 | 13 | 43 | 47 | 32 | 137 |
| Depression | D003863 | — | F33.9 | 8 | 9 | 18 | 24 | 14 | 70 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 9 | 10 | 16 | 21 | 18 | 69 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 6 | 3 | 3 | 12 | 12 | 34 |
| Mania | D000087122 | — | — | — | 1 | 7 | 8 | 1 | 17 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 3 | 1 | 4 | 4 | 12 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | 3 | 1 | 3 | 6 | 12 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | 4 | 5 | 11 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | 1 | 3 | 3 | 8 |
| Wounds and injuries | D014947 | — | T14.8 | 2 | 3 | — | 1 | 3 | 8 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Suicide | D013405 | — | — | — | 2 | 3 | — | 4 | 7 |
| Sclerosis | D012598 | — | — | 1 | 5 | 2 | — | — | 6 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 4 | 2 | — | — | 5 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 4 | 2 | — | — | 5 |
| Attempted suicide | D013406 | EFO_0004321 | T14.91 | — | 2 | 2 | — | 2 | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 2 | — | 2 | 4 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | 2 | 3 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | — | 1 | — | 2 | 3 |
| Ataxia | D001259 | — | R27.0 | 1 | 2 | 1 | — | — | 3 |
| Spinocerebellar degenerations | D013132 | — | G11 | 1 | 2 | 1 | — | — | 3 |
Show 19 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | 4 | 5 | — | — | — | 6 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | 5 | — | — | — | 5 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 2 | — | — | 1 | 4 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | 2 | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 4 | 2 | — | — | — | 4 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 2 | 1 | — | — | 1 | 3 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | 2 | — | — | 1 | 3 |
| Shock | D012769 | — | R57.1 | — | 1 | — | — | 1 | 2 |
| Dysthymic disorder | D019263 | EFO_0008623 | F34.1 | — | 1 | — | — | 1 | 2 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | 1 | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | 1 | 2 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 1 | — | — | — | 1 | 2 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | 1 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| T-cell lymphoma | D016399 | — | — | 1 | — | — | — | 1 | 2 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | 1 | 2 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 13 | 13 |
| Nonvital tooth | D019553 | — | — | — | — | — | — | 11 | 11 |
| Tooth discoloration | D014075 | — | K03.6 | — | — | — | — | 7 | 7 |
| Tooth fractures | D014082 | — | S02.5 | — | — | — | — | 7 | 7 |
| Prosthesis failure | D011475 | — | — | — | — | — | — | 5 | 5 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 4 | 4 |
| Dental implants | D015921 | — | — | — | — | — | — | 4 | 4 |
| Tooth loss | D016388 | — | — | — | — | — | — | 4 | 4 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lithium |
| INN | — |
| Description | Lithium Citrate, Lithonate (lithium) is a small molecule pharmaceutical. Lithium was first approved as Lithium Citrate on 1982-01-01. It is used to treat in the USA. The pharmaceutical is active against inositol monophosphatase 1. In addition, it is known to target glycogen synthase kinase-3 beta. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | [LiH] |
Identifiers
| PDB | — |
| CAS-ID | 7439-93-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2146126 |
| ChEBI ID | 30146 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
Target
Agency Approved
IMPA1
IMPA1
Organism
Homo sapiens
Gene name
IMPA1
Gene synonyms
IMPA
NCBI Gene ID
Protein name
inositol monophosphatase 1
Protein synonyms
D-galactose 1-phosphate phosphatase, IMP 1, IMPase 1, inositol(myo)-1(or 4)-monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1, myo-inositol monophosphatase 1, testicular tissue protein Li 94
Uniprot ID
Mouse ortholog
Impa1 (55980)
inositol monophosphatase 1 (O55023)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Lithium
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 53,788 documents
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Safety
Black-box Warning
Black-box warning for: Lithane, Lithium, Lithium carbonate, Lithium carbonate lithium carbonate, Lithium lithium carbonate, Lithobid
Adverse Events
Top Adverse Reactions
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20,896 adverse events reported
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