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Drug ReportsLisinopril
Lisinopril
Lisinopril, Qbrelis, Zestoretic, Zestril (lisinopril) is a small molecule pharmaceutical. Lisinopril was first approved as Prinivil on 1987-12-29. It is used to treat diabetic nephropathies, heart failure, hypertension, left ventricular dysfunction, and myocardial infarction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Lisinopril, Qbrelis, Zestril (discontinued: Lisinopril, Prinivil)
Combinations
Lisinopril hydrochlorothiazide, Zestoretic (discontinued: Lisinopril hydrochlorothiazide, Prinzide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lisinopril
Tradename
Company
Number
Date
Products
QBRELISAzurityN-208401 RX2016-07-29
1 products, RLD, RS
ZESTRILTWi PharmaceuticalsN-019777 RX1988-05-19
6 products, RLD, RS
Show 1 discontinued
Hydrochlorothiazide
+
Lisinopril
Tradename
Company
Number
Date
Products
ZESTORETICAlmatica PharmaN-019888 RX1989-07-20
3 products, RLD
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
lisinoprilANDA2025-10-02
lisinopril and hctzANDA2014-07-23
lisinopril and hydrochlorothiazideANDA2025-09-17
lisinopril lisinoprilANDA2012-10-01
lisinopril lisinopril/hctzANDA2019-04-18
lisinopril with hydrochlorothiazideANDA2013-06-04
lisinopril-hydrochlorothiazideANDA2013-03-07
lisinopril/hctzANDA2022-10-05
lisinorilANDA2022-10-05
lytensoprilunapproved drug other2011-08-01
Show 5 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
diabetic nephropathiesEFO_0000401D003928—
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
myocardial infarctionEFO_0000612D009203I21
nephrotic syndromeEFO_0004255D009404N04
edema—D004487R60.9
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Lisinopril, Qbrelis, Azurity
94631832035-11-06DP
96160962035-11-06U-3, U-8, U-71, U-185, U-1723, U-1864, U-1991
98147512035-11-06DP
100398002035-11-06U-3, U-8, U-71, U-185, U-1723, U-1864, U-1991
102653702035-11-06DP
104061992035-11-06U-3, U-8, U-71, U-185, U-1723, U-1864, U-1991
109401772035-11-06DP
111794342035-11-06DP
117717332035-11-06DP
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA03: Lisinopril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA03: Lisinopril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB03: Lisinopril and amlodipine
— C10: Lipid modifying agents
— C10B: Lipid modifying agents, combinations
— C10BX: Lipid modifying agents in combination with other drugs
— C10BX07: Rosuvastatin, amlodipine and lisinopril
HCPCS
No data
Clinical
Clinical Trials
154 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Kidney diseasesD007674EFO_0003086N08——2——2
Polycystic kidney diseasesD007690—Q61.3——2——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLisinopril
INNlisinopril
Description
Lisinopril is a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a L-prolino group and a L-lysine residue.
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O.O.O
Identifiers
PDB—
CAS-ID83915-83-7
RxCUI—
ChEMBL IDCHEMBL419213
ChEBI ID6503
PubChem CID5362119
DrugBankDB00722
UNII ID7Q3P4BS2FD (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Lisinopril
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Lisinopril
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,732 documents
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Safety
Black-box Warning
Black-box warning for: Lisinopril, Lisinopril and hctz, Lisinopril and hydrochlorothiazide, Lisinopril lisinopril/hctz, Lisinopril with hydrochlorothiazide, Lisinopril-hydrochlorothiazide, Lisinopril/hctz, Lisinoril, Lytensopril, Lytensopril-90, Qbrelis, Zestoretic, Zestril, Ziprasidone hydrochloride
Adverse Events
Top Adverse Reactions
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57,007 adverse events reported
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