Victoza(liraglutide)
Saxenda, Victoza, Xultophy (liraglutide) is a protein pharmaceutical. Liraglutide was first approved as Victoza on 2009-06-30. It has been approved in Europe to treat obesity, overweight, and type 2 diabetes mellitus. The pharmaceutical is active against glucagon-like peptide 1 receptor.
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Commercial
Trade Name
FDA
EMA
Saxenda, Victoza
CombinationsXultophy
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Insulin degludec
+
Liraglutide
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Xultophy 100/3.6 | insulin degludec and liraglutide | Novo Nordisk | N-208583 RX | 2016-11-21 | 1 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| liraglutide | NDA authorized generic | 2024-01-01 |
| saxenda | New Drug Application | 2024-01-26 |
| victoza | New Drug Application | 2023-07-05 |
| xultophy 100/3.6 | Biologic Licensing Application | 2023-07-10 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
LIRAGLUTIDE RECOMBINANT, SAXENDA, NOVO | |||
| 2023-12-04 | NPP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Liraglutide Recombinant, Saxenda, Novo | |||
| 9968659 | 2037-01-09 | U-2313, U-2438 | |
| 9132239 | 2032-02-01 | DP | |
| 9457154 | 2027-09-27 | DP | |
| 9687611 | 2027-02-27 | DP | |
| RE46363 | 2026-08-03 | DP | |
| 8920383 | 2026-07-17 | DP | |
| 9775953 | 2026-07-17 | DP | |
| 10220155 | 2026-07-17 | DP | |
| 11097063 | 2026-07-17 | DP | |
| 9108002 | 2026-01-26 | DP | |
| 9616180 | 2026-01-20 | DP | |
| 9861757 | 2026-01-20 | DP | |
| 10357616 | 2026-01-20 | DP | |
| 10376652 | 2026-01-20 | DP | |
| 11311679 | 2026-01-20 | DP | |
| 8684969 | 2025-10-20 | DP | |
| 11446443 | 2025-10-20 | DP | |
| 8114833 | 2025-08-13 | DS, DP | |
| 7762994 | 2024-05-23 | DP | |
| 8579869 | 2023-06-30 | DP | |
| Liraglutide Recombinant, Victoza, Novo Nordisk Inc | |||
| 9265893 | 2032-09-23 | DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10A: Insulins and analogues
— A10AE: Insulins and analogues for injection, long-acting
— A10AE56: Insulin degludec and liraglutide
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BJ: Glucagon-like peptide-1 (glp-1) analogues
— A10BJ02: Liraglutide
HCPCS
No data
Clinical
Clinical Trials
489 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 49 | 38 | 77 | 46 | 56 | 258 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 31 | 30 | 67 | 62 | 69 | 255 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 13 | 14 | 22 | 39 | 26 | 113 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 7 | 15 | 14 | 5 | 4 | 39 |
| Overweight | D050177 | — | E66.3 | 5 | 4 | 8 | 10 | 7 | 34 |
| Weight loss | D015431 | HP_0001824 | — | — | 3 | 6 | 9 | 12 | 30 |
| Healthy volunteers/patients | — | — | — | 21 | — | — | 3 | 3 | 27 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 2 | 1 | 7 | 4 | 14 |
| Body weight | D001835 | EFO_0004338 | — | — | 2 | 6 | 1 | 3 | 12 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | 3 | 8 | — | 11 |
Show 64 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nutrition disorders | D009748 | EFO_0001069 | — | 7 | 2 | 8 | — | 1 | 18 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 2 | 1 | — | — | 3 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | 1 | 1 | 1 | — | 1 | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | 1 | — | — | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | 1 | — | 1 | 2 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 1 | — | 1 | 2 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | — | 1 | — | 1 | 2 |
| Feeding and eating disorders | D001068 | — | F50 | — | — | 1 | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 1 | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | 3 | — | — | 5 | 8 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | 3 | 4 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | — | 2 | 3 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | 2 | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | 1 | 2 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | 1 | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | 1 | — | — | — | 1 |
| Opiate substitution treatment | D058850 | — | — | 1 | 1 | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | — | 1 | — | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | 1 | — | — | — | 1 |
Show 12 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pediatric obesity | D063766 | — | — | 1 | — | — | — | 1 | 2 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | 1 | — | — | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Post-acute covid-19 syndrome | D000094024 | — | — | 1 | — | — | — | — | 1 |
| Craniopharyngioma | D003397 | — | — | 1 | — | — | — | — | 1 |
| Hypopituitarism | D007018 | EFO_0001380 | E23.0 | 1 | — | — | — | — | 1 |
| Adamantinoma | D050398 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 3 | 3 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | — | 3 | 3 |
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | — | — | — | 3 | 3 |
| Carcinoma | D002277 | — | C80.0 | — | — | — | — | 1 | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | — | — | — | 1 | 1 |
| Neuroendocrine carcinoma | D018278 | — | — | — | — | — | — | 1 | 1 |
| Papillary thyroid cancer | D000077273 | — | — | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | — | 1 | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
Show 26 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Liraglutide |
| INN | liraglutide |
| Description | Liraglutide is a lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a glucagon-like peptide-1 receptor agonist and a neuroprotective agent. It is a lipopeptide and a polypeptide. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O)C(C)C)[C@@H](C)CC)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 204656-20-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4524066 |
| ChEBI ID | — |
| PubChem CID | 16134956 |
| DrugBank | DB06655 |
| UNII ID | 839I73S42A (ChemIDplus, GSRS) |
Target
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Saxenda – Novo Nordisk
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Victoza – Novo Nordisk
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Xultophy – Novo Nordisk
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Estimated US medical usage
Liraglutide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
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Additional graphs summarizing 17,144 documents
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Safety
Black-box Warning
Black-box warning for: Liraglutide, Saxenda, Victoza, Xultophy 100/3.6
Adverse Events
Top Adverse Reactions
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38,860 adverse events reported
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