Liothyronine
Cytomel, Liothyronine (liothyronine) is a small molecule pharmaceutical. Liothyronine was first approved as Cytomel on 1982-01-01. It is used to treat autoimmune thyroiditis, goiter, myxedema, thyroid neoplasms, and thyrotoxicosis in the USA. The pharmaceutical is active against thyroid hormone receptor beta and thyroid hormone receptor alpha.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Cytomel, Liothyronine (discontinued: Liothyronine, Triostat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Liothyronine sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CYTOMEL | King Pharmaceuticals | N-010379 RX | 1982-01-01 | 3 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adthyza | unapproved drug other | 2023-02-23 |
| adthyza thyroid | unapproved drug other | 2023-12-08 |
| cytomel | New Drug Application | 2019-07-24 |
| liothyronine sodium | ANDA | 2024-10-16 |
| np thyroid | unapproved drug other | 2021-05-11 |
| np thyroid 120 | unapproved drug other | 2024-10-15 |
| np thyroid 15 | unapproved drug other | 2024-10-29 |
| np thyroid 30 | unapproved drug other | 2024-10-29 |
| np thyroid 60 | unapproved drug other | 2024-10-30 |
| np thyroid 90 | unapproved drug other | 2024-11-13 |
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Indications
FDA
EMA
Agency Specific
FDA
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No data
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No data
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No data
Clinical
No data
Drug
General
| Drug common name | Liothyronine |
| INN | liothyronine |
| Description | 3,3',5-triiodo-L-thyronine is an iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. It has a role as a thyroid hormone, a human metabolite and a mouse metabolite. It is an iodophenol, a 2-halophenol and an iodothyronine. It is a conjugate acid of a 3,3',5-triiodo-L-thyroninate. It is a tautomer of a 3,3',5-triiodo-L-thyronine zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 6893-02-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1544 |
| ChEBI ID | 18258 |
| PubChem CID | 5920 |
| DrugBank | DB00279 |
| UNII ID | 06LU7C9H1V (ChemIDplus, GSRS) |
Target
Agency Approved
THRA
THRA
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Alternate
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No data
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Estimated US medical usage
Liothyronine
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Safety
Black-box Warning
Black-box warning for: Adthyza, Adthyza thyroid, Cytomel, Liothyronine sodium, Np thyroid 60, Np thyroid 90
Adverse Events
0 adverse events reported
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