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AboutPricing
Drug ReportsLiothyronine
Liothyronine
Cytomel, Liothyronine (liothyronine) is a small molecule pharmaceutical. Liothyronine was first approved as Cytomel on 1982-01-01. It is used to treat autoimmune thyroiditis, goiter, myxedema, thyroid neoplasms, and thyrotoxicosis in the USA. The pharmaceutical is active against thyroid hormone receptor beta and thyroid hormone receptor alpha.
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
Trade Name
FDA
EMA
Cytomel, Liothyronine (discontinued: Liothyronine, Triostat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Liothyronine sodium
Tradename
Company
Number
Date
Products
CYTOMELKing PharmaceuticalsN-010379 RX1982-01-01
3 products, RLD
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adthyzaunapproved drug other2023-02-23
adthyza thyroidunapproved drug other2025-02-20
cytomelNew Drug Application2025-04-04
liothyronine sodiumANDA2025-03-12
np thyroidunapproved drug other2021-05-11
np thyroid 120unapproved drug other2025-03-05
np thyroid 15unapproved drug other2025-03-06
np thyroid 30unapproved drug other2025-03-06
np thyroid 60unapproved drug other2025-03-06
np thyroid 90unapproved drug other2025-03-06
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
thyroid neoplasmsEFO_0003841D013964—
autoimmune thyroiditisEFO_0006812D013967E06.3
goiterEFO_0004283D006042E04.9
thyrotoxicosis—D013971E05
myxedemaEFO_1001055D009230E03.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H03: Thyroid therapy drugs
— H03A: Thyroid preparations
— H03AA: Thyroid hormones
— H03AA02: Liothyronine sodium
— H03AA03: Combinations of levothyroxine and liothyronine
HCPCS
No data
Clinical
Clinical Trials
773 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLiothyronine
INNliothyronine
Description
3,3',5-triiodo-L-thyronine is an iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. It has a role as a thyroid hormone, a human metabolite and a mouse metabolite. It is an iodophenol, a 2-halophenol and an iodothyronine. It is a conjugate acid of a 3,3',5-triiodo-L-thyroninate. It is a tautomer of a 3,3',5-triiodo-L-thyronine zwitterion.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
Identifiers
PDB—
CAS-ID6893-02-3
RxCUI—
ChEMBL IDCHEMBL1544
ChEBI ID18258
PubChem CID5920
DrugBankDB00279
UNII ID06LU7C9H1V (ChemIDplus, GSRS)
Target
Agency Approved
THRA
THRA
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
7067
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
P10827
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Liothyronine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 159,196 documents
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Safety
Black-box Warning
Black-box warning for: Adthyza, Adthyza thyroid, Cytomel, Liothyronine sodium, Np thyroid 60, Np thyroid 90
Adverse Events
Top Adverse Reactions
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4,653 adverse events reported
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