Tradename | Company | Number | Date | Products |
---|---|---|---|---|
LINEZOLID IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | Hospira | N-206473 RX | 2015-06-18 | 1 products, RLD, RS |
ZYVOX | Pfizer | N-021130 RX | 2000-04-18 | 1 products, RLD, RS |
ZYVOX | Pfizer | N-021131 RX | 2000-04-18 | 2 products, RLD, RS |
ZYVOX | Pfizer | N-021132 RX | 2000-04-18 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
linezolid | ANDA | 2025-06-13 |
linezolid for oral solution | ANDA | 2015-11-18 |
zyvox | New Drug Application | 2024-09-25 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Infections | D007239 | EFO_0000544 | — | — | 1 | 5 | 2 | 1 | 9 |
Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 1 | 4 | 4 | 9 |
Bacterial infections | D001424 | — | A49 | 1 | — | 4 | 1 | 1 | 7 |
Gram-positive bacterial infections | D016908 | — | — | 1 | — | 3 | 1 | 1 | 6 |
Communicable diseases | D003141 | — | — | — | — | 5 | 1 | — | 6 |
Staphylococcal infections | D013203 | — | A49.01 | — | — | — | 3 | 2 | 5 |
Methicillin-resistant staphylococcus aureus | D055624 | — | — | — | — | — | 3 | 1 | 4 |
Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | 2 | 1 | 3 |
Healthcare-associated pneumonia | D000077299 | — | — | — | — | — | 1 | 2 | 3 |
Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | 1 | — | 1 | 2 |
Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 2 | — | — | 2 |
Neutropenia | D009503 | — | D70 | — | — | 1 | — | — | 1 |
Fever | D005334 | — | R50.9 | — | — | 1 | — | — | 1 |
Febrile neutropenia | D064147 | — | — | — | — | 1 | — | — | 1 |
Hyperthermia | D000084462 | — | — | — | — | 1 | — | — | 1 |
Nervous system diseases | D009422 | — | G00-G99 | — | — | 1 | — | — | 1 |
Optic nerve diseases | D009901 | EFO_1001330 | H47.14 | — | — | 1 | — | — | 1 |
Cross infection | D003428 | — | — | — | — | 1 | — | — | 1 |
Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | 2 | 3 |
Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
Streptococcal infections | D013290 | EFO_1001476 | — | — | 1 | — | — | 1 | 2 |
Fibrosis | D005355 | — | — | — | 1 | — | — | — | 1 |
Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | — | 1 |
Staphylococcal skin infections | D013207 | EFO_1001849 | L00 | — | 1 | — | — | — | 1 |
Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | — | 1 |
Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | — | — | — | 1 |
Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | — | — | — | 1 |
Osteoarticular tuberculosis | D014394 | EFO_0007487 | A18.0 | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
Neurosurgical procedures | D019635 | — | — | 1 | — | — | — | — | 1 |
Burns | D002056 | — | T30.0 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Septic shock | D012772 | — | A48.3 | — | — | — | — | 4 | 4 |
Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | — | 3 | 3 |
Renal insufficiency | D051437 | — | N19 | — | — | — | — | 2 | 2 |
Shock | D012769 | — | R57.1 | — | — | — | — | 2 | 2 |
Inappropriate prescribing | D057970 | — | — | — | — | — | — | 1 | 1 |
Bacterial meningitis | D016920 | EFO_1000831 | G00 | — | — | — | — | 1 | 1 |
Prosthesis-related infections | D016459 | EFO_1001406 | — | — | — | — | — | 1 | 1 |
Asymptomatic infections | D058345 | — | — | — | — | — | — | 1 | 1 |
Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
Cerebral hemorrhage | D002543 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Linezolid |
INN | linezolid |
Description | Linezolid is an organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. It has a role as an antibacterial drug and a protein synthesis inhibitor. It is an oxazolidinone, a member of morpholines, an organofluorine compound and a member of acetamides. |
Classification | Small molecule |
Drug class | oxazolidinone antibacterials |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1 |
PDB | — |
CAS-ID | 165800-03-3 |
RxCUI | — |
ChEMBL ID | CHEMBL126 |
ChEBI ID | 63607 |
PubChem CID | 441401 |
DrugBank | DB00601 |
UNII ID | ISQ9I6J12J (ChemIDplus, GSRS) |