Tradename | Company | Number | Date | Products |
---|---|---|---|---|
SYNTHROID | AbbVie | N-021402 RX | 2002-07-24 | 12 products, RLD |
THYRO-TABS | Alvogen | N-021116 RX | 2002-10-24 | 12 products, RLD |
THYQUIDITY | Azurity | N-214047 RX | 2020-11-30 | 1 products, RLD, RS |
LEVO-T | Cediprof | N-021342 RX | 2002-03-01 | 12 products |
LEVOTHYROXINE SODIUM | Fresenius Kabi | N-202231 RX | 2011-06-24 | 3 products, RLD, RS |
LEVOTHYROXINE SODIUM | Fresenius Kabi | N-210632 RX | 2019-04-11 | 3 products, RLD, RS |
LEVOLET | Genus Lifesciences | N-021137 RX | 2003-06-06 | 12 products |
LEVOTHYROXINE SODIUM | Hikma Pharmaceuticals | N-214253 RX | 2021-05-17 | 1 products, RLD, RS |
TIROSINT | IBSA Group | N-021924 RX | 2006-10-13 | 15 products, RLD |
TIROSINT-SOL | IBSA Group | N-206977 RX | 2016-12-15 | 15 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
adthyza | unapproved drug other | 2023-02-23 |
adthyza thyroid | unapproved drug other | 2025-02-20 |
ermeza | New Drug Application | 2022-04-15 |
euthyrox | New Drug Application | 2024-10-24 |
levo-t | New Drug Application | 2024-07-31 |
levothroid | New Drug Application | 2012-03-02 |
levothyroxine | NDA authorized generic | 2014-09-24 |
levothyroxine sodium | ANDA | 2025-03-20 |
levoxyl | New Drug Application | 2020-12-15 |
np thyroid | unapproved drug other | 2021-05-11 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Levothyroxine Sodium, Tirosint-Sol, Ibsa | |||
11241382 | 2039-09-17 | U-3757, U-3758 | |
10537538 | 2037-02-28 | DP | |
11096913 | 2037-02-28 | DP | |
Levothyroxine Sodium, Levolet, Genus Lifesciences | |||
10231931 | 2038-03-23 | DP | |
10406108 | 2038-03-23 | DP | |
Levothyroxine Sodium, Levothyroxine Sodium, Fresenius Kabi Usa | |||
9782376 | 2036-12-01 | DP | |
10398669 | 2036-12-01 | DP | |
11135190 | 2036-12-01 | DP | |
9006289 | 2032-10-03 | DP | |
9168238 | 2032-08-29 | DP | |
9168239 | 2032-08-29 | DP | |
Levothyroxine Sodium, Levothyroxine Sodium, Hikma | |||
11154498 | 2036-07-20 | DP | |
Levothyroxine Sodium, Ermeza, Mylan | |||
9345772 | 2035-02-27 | DP | |
Levothyroxine Sodium, Thyquidity, Azurity | |||
9050307 | 2031-08-06 | DP | |
Levothyroxine Sodium, Tirosint, Ibsa | |||
7691411 | 2024-03-14 | DP | |
7723390 | 2024-03-14 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypothyroidism | D007037 | EFO_0004705 | E03.9 | 5 | 16 | 12 | 32 | 60 | 118 |
Thyroid diseases | D013959 | — | E00-E07 | 2 | 10 | 4 | 8 | 33 | 55 |
Thyroid neoplasms | D013964 | EFO_0003841 | — | 2 | 6 | 3 | 2 | 15 | 27 |
Healthy volunteers/patients | — | — | — | 13 | 1 | — | 2 | 1 | 16 |
Graves disease | D006111 | EFO_0004237 | E05.0 | — | 1 | 3 | 3 | 3 | 9 |
Congenital hypothyroidism | D003409 | — | E00.1 | — | — | — | 2 | 7 | 9 |
Syndrome | D013577 | — | — | — | — | 1 | 1 | 4 | 6 |
Recurrence | D012008 | — | — | 1 | 1 | 1 | 2 | 1 | 6 |
Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 1 | — | 1 | 1 | 5 |
Goiter | D006042 | EFO_0004283 | E04.9 | — | 1 | — | 3 | 1 | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hashimoto disease | D050031 | EFO_0003779 | E06.3 | — | 1 | 1 | — | 10 | 12 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 1 | — | 4 | 5 |
Dyslipidemias | D050171 | — | — | — | — | 2 | — | 2 | 4 |
Premature birth | D047928 | EFO_0003917 | O60 | — | — | 2 | — | 2 | 4 |
Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | 2 | 3 |
Chronic renal insufficiency | D051436 | — | N18 | — | — | 1 | — | 2 | 3 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | — | 2 | 3 |
Thyrotoxicosis | D013971 | — | E05 | — | 1 | 1 | — | 1 | 3 |
Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | 1 | — | 1 | — | 1 | 3 |
Habitual abortion | D000026 | EFO_1000954 | N96 | 1 | — | 1 | — | 1 | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Thyroiditis | D013966 | — | E06 | — | 1 | — | — | 10 | 11 |
Autoimmune thyroiditis | D013967 | EFO_0006812 | E06.3 | — | 1 | — | — | 8 | 9 |
Infertility | D007246 | EFO_0000545 | — | — | 2 | — | — | 3 | 5 |
Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 2 | — | — | — | 3 |
Fatty liver | D005234 | EFO_0003934 | — | 1 | 2 | — | — | — | 3 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | 1 | — | — | — | 2 |
Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
Alveolar soft part sarcoma | D018234 | — | — | — | 1 | — | — | — | 1 |
Environmental biomarkers | D000074062 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hyperthyroidism | D006980 | — | E05.9 | 1 | — | — | — | 5 | 6 |
Melanosis | D008548 | EFO_0003963 | L81.1 | 1 | — | — | — | 1 | 2 |
Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Anemia | D000740 | EFO_0004272 | D64.9 | 1 | — | — | — | — | 1 |
Iron-deficiency anemia | D018798 | — | D50 | 1 | — | — | — | — | 1 |
Deficiency diseases | D003677 | EFO_1001067 | E63 | 1 | — | — | — | — | 1 |
Iron deficiencies | D000090463 | — | E61.1 | 1 | — | — | — | — | 1 |
Heart transplantation | D016027 | EFO_0010673 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pregnancy rate | D018873 | — | — | — | — | — | — | 4 | 4 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 4 | 4 |
Carcinoma | D002277 | — | C80.0 | — | — | — | — | 3 | 3 |
Hyperprolactinemia | D006966 | — | E22.1 | — | — | — | — | 2 | 2 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | — | 2 | 2 |
Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | — | 2 | 2 |
Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | — | — | — | 2 | 2 |
Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 2 | 2 |
Keratoconus | D007640 | EFO_0004223 | H18.6 | — | — | — | — | 2 | 2 |
Hormone replacement therapy | D020249 | EFO_0003961 | Z79.890 | — | — | — | — | 2 | 2 |
Drug common name | Levothyroxine |
INN | levothyroxine sodium |
Description | L-thyroxine is the L-enantiomer of thyroxine. It has a role as a thyroid hormone, an antithyroid drug, a human metabolite and a mouse metabolite. It is a thyroxine, an iodophenol, a 2-halophenol, a L-phenylalanine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-thyroxine(1-). It is an enantiomer of a D-thyroxine. It is a tautomer of a L-thyroxine zwitterion. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O |
PDB | — |
CAS-ID | 51-48-9 |
RxCUI | — |
ChEMBL ID | CHEMBL1624 |
ChEBI ID | 18332 |
PubChem CID | 5819 |
DrugBank | DB00451 |
UNII ID | 054I36CPMN (ChemIDplus, GSRS) |