Levosimendan
Levosimendan is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
114 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | 7 | 9 | 16 | 16 | 48 |
| Cardiogenic shock | D012770 | — | R57.0 | — | 1 | 3 | 2 | 8 | 13 |
| Low cardiac output | D002303 | — | — | 1 | 4 | 2 | 1 | 1 | 7 |
| Septic shock | D012772 | — | A48.3 | — | 3 | 2 | 1 | 2 | 6 |
| Cardiac surgical procedures | D006348 | — | — | — | 1 | — | 1 | 4 | 6 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | 2 | 2 | 4 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | 2 | 1 | 4 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | 2 | 1 | 4 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | — | 2 | 1 | 3 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Shock | D012769 | — | R57.1 | — | 3 | 4 | — | 8 | 13 |
| Left ventricular dysfunction | D018487 | — | — | — | 1 | 2 | — | 3 | 6 |
| Ventricular dysfunction | D018754 | — | — | — | 2 | 2 | — | 3 | 6 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 2 | 1 | — | 2 | 5 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | 1 | — | 2 | 4 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | 2 | — | — | 3 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | 2 | — | — | 3 |
| Right ventricular dysfunction | D018497 | — | — | — | 1 | 2 | — | 1 | 3 |
| Cardio-renal syndrome | D059347 | — | — | — | — | 1 | — | 2 | 3 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital heart defects | D006330 | — | Q24.9 | 1 | 2 | — | — | 1 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | — | — | 1 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | — | — | — | 2 |
| Transposition of great vessels | D014188 | — | Q20.3 | — | 1 | — | — | — | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Femoral fractures | D005264 | — | S72 | — | — | — | — | 1 | 1 |
| Sprains and strains | D013180 | — | — | — | — | — | — | 1 | 1 |
| Physiologic monitoring | D008991 | — | — | — | — | — | — | 1 | 1 |
| Heart murmurs | D006337 | — | R01.0 | — | — | — | — | 1 | 1 |
| Physiological phenomena | D010829 | — | — | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 1 | 1 |
| Toxemia | D014115 | — | — | — | — | — | — | 1 | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levosimendan |
| INN | levosimendan |
| Description | Levosimendan is a hydrazone, a pyridazinone and a nitrile. It has a role as a vasodilator agent, an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor, a cardiotonic drug and an anti-arrhythmia drug. |
| Classification | Small molecule |
| Drug class | positive inotropic agents (pimobendan type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 141505-33-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2051955 |
| ChEBI ID | 50567 |
| PubChem CID | 3033825 |
| DrugBank | DB00922 |
| UNII ID | C6T4514L4E (ChemIDplus, GSRS) |
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Trends
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Safety
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Adverse Events
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199 adverse events reported
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