Levosimendan
Levosimendan is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 3 | — | — | 3 |
| Septic shock | D012772 | — | A48.3 | — | 1 | 1 | — | — | 1 |
| Shock | D012769 | — | R57.1 | — | 1 | 1 | — | — | 1 |
| Cardiogenic shock | D012770 | — | R57.0 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levosimendan |
| INN | levosimendan |
| Description | Levosimendan is a hydrazone, a pyridazinone and a nitrile. It has a role as a vasodilator agent, an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor, a cardiotonic drug and an anti-arrhythmia drug. |
| Classification | Small molecule |
| Drug class | positive inotropic agents (pimobendan type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 141505-33-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2051955 |
| ChEBI ID | 50567 |
| PubChem CID | 3033825 |
| DrugBank | DB00922 |
| UNII ID | C6T4514L4E (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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181 adverse events reported
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