LEVORPHANOL
Levorphanol (levorphanol) is a small molecule pharmaceutical. Levorphanol was first approved as Levo-dromoran on 1991-12-19. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target glutamate receptor ionotropic, NMDA 2C.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Levorphanol (discontinued: Levo-dromoran, Levorphanol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levorphanol tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LEVO-DROMORAN | Bausch Health Companies | N-008719 DISCN | 1991-12-19 | 1 products |
| LEVO-DROMORAN | Bausch Health Companies | N-008720 DISCN | 1991-12-19 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| levorphanol tartrate | ANDA | 2024-08-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code | Description |
|---|---|
| J1960 | Injection, levorphanol tartrate, up to 2 mg |
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEVORPHANOL |
| INN | levorphanol |
| Description | Levorphanol is a morphinane alkaloid. |
| Classification | Small molecule |
| Drug class | narcotic antagonists/agonists (morphinan derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13 |
Identifiers
| PDB | — |
| CAS-ID | 77-07-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL592 |
| ChEBI ID | 6444 |
| PubChem CID | 5359272 |
| DrugBank | DB00854 |
| UNII ID | 27618J1N2X (ChemIDplus, GSRS) |
Target
Alternate
GRIN2C
GRIN2C
Organism
Homo sapiens
Gene name
GRIN2C
Gene synonyms
NMDAR2C
NCBI Gene ID
Protein name
glutamate receptor ionotropic, NMDA 2C
Protein synonyms
GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), GluN2C(del_e2), GluN2C-b alternative isoform, Glutamate [NMDA] receptor subunit epsilon-3, glutamate receptor, ionotropic, N-methyl D-aspartate 2C, N-methyl D-aspartate receptor subtype 2C, N-methyl-D-aspartate receptor subunit 2C, NMDAR2C, NR2C, putative NMDtranscript(altAcc_e11), putative NMDtranscript(altDon_e4), putative NMDtranscript(del_e4)
Uniprot ID
Mouse ortholog
Grin2c (14813)
glutamate receptor ionotropic, NMDA 2C (Q01098)
Variants
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Financial
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Estimated US medical usage
Levorphanol
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 962 documents
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Safety
Black-box Warning
Black-box warning for: Levorphanol tartrate
Adverse Events
Top Adverse Reactions
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367 adverse events reported
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