Levonordefrin
Carbocaine, Carbocaine W/ Neo-cobefrin, Ravocaine Novocain W/, Ravocaine Novocain W/ Neo-cobefrin, Scandonest L (levonordefrin) is a small molecule pharmaceutical. Levonordefrin was first approved as Carbocaine w/ neo-cobefrin on 1982-01-01. It is used to treat oral ulcer and toothache in the USA. It is known to target alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| stomatognathic diseases | D009057 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Norepinephrine bitartrate
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAVOCAINE AND NOVOCAIN W/ LEVOPHED | Eastman Kodak | N-008592 DISCN | 1982-01-01 | 1 products |
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Levonordefrin
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN | Eastman Kodak | N-008592 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| isocaine isocaine with levonordefrin | 2007-03-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| toothache | — | D014098 | K08.89 |
| oral ulcer | — | D019226 | — |
| substance withdrawal syndrome | EFO_0005800 | D013375 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Local anesthesia | D000772 | — | — | — | 1 | 1 | — | 1 | 3 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 2 | 2 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Edema | D004487 | — | R60.9 | — | — | — | — | 1 | 1 |
| Trismus | D014313 | — | — | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 1 | 1 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 1 | 1 |
| Liver failure | D017093 | — | K72.9 | — | — | — | — | 1 | 1 |
| Hepatic insufficiency | D048550 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levonordefrin |
| INN | corbadrine |
| Description | Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 829-74-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL677 |
| ChEBI ID | 10304 |
| PubChem CID | 164739 |
| DrugBank | DB06707 |
| UNII ID | V008L6478D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (Q61619)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 219 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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27 adverse events reported
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