Levonordefrin
Carbocaine, Carbocaine W/ Neo-cobefrin, Ravocaine Novocain W/, Ravocaine Novocain W/ Neo-cobefrin, Scandonest L (levonordefrin) is a small molecule pharmaceutical. Levonordefrin was first approved as Carbocaine w/ neo-cobefrin on 1982-01-01. It is used to treat oral ulcer and toothache in the USA. It is known to target alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| stomatognathic diseases | D009057 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Norepinephrine bitartrate
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAVOCAINE AND NOVOCAIN W/ LEVOPHED | Eastman Kodak | N-008592 DISCN | 1982-01-01 | 1 products |
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Levonordefrin
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN | Eastman Kodak | N-008592 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| carbocaine | ANDA | 2024-02-21 |
| carbocaine carbocaine with neo-cobefrin | ANDA | 2017-12-12 |
| isocaine isocaine with levonordefrin | 2007-03-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| toothache | — | D014098 | K08.89 |
| oral ulcer | HP_0000155 | D019226 | — |
| substance withdrawal syndrome | EFO_0005800 | D013375 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
145 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | — | 4 | 11 | 15 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 2 | 3 | 8 | 13 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | 5 | 4 | 10 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | 1 | 1 | 3 | 6 | 10 |
| Local anesthesia | D000772 | — | — | — | 2 | 2 | 2 | 2 | 8 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 2 | 2 | 2 | 6 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | 4 | 1 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 2 | 1 | 2 | 5 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | 1 | 1 | 3 | — | 4 |
| Nerve block | D009407 | — | — | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rupture | D012421 | — | — | — | — | 1 | — | 2 | 3 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | 1 | — | 2 | 3 |
| Forearm injuries | D005543 | — | S59.91 | — | — | 1 | — | 1 | 2 |
| Intervertebral disc degeneration | D055959 | HP_0008419 | — | 1 | 1 | 1 | — | — | 2 |
| Radiculopathy | D011843 | — | M54.1 | — | — | 1 | — | 1 | 2 |
| Job syndrome | D007589 | EFO_0003775 | D82.4 | — | — | 1 | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 1 | — | — | 1 |
| Wrist fractures | D000092503 | — | — | — | — | 1 | — | — | 1 |
| Emergencies | D004630 | — | — | — | — | 1 | — | — | 1 |
| Analgesia | D000698 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | HP_0003419 | M54.5 | 1 | 1 | — | — | 3 | 4 |
| Knee injuries | D007718 | — | — | — | 1 | — | — | 1 | 2 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 1 | — | — | 1 | 2 |
| Covid-19 | D000086382 | — | — | 1 | 2 | — | — | — | 2 |
| Olfaction disorders | D000857 | HP_0000458 | R43.0 | 1 | 2 | — | — | — | 2 |
| Peri-implantitis | D057873 | EFO_1001390 | — | — | 1 | — | — | — | 1 |
| Periodontal diseases | D010510 | — | K05.6 | — | 1 | — | — | — | 1 |
| Back pain | D001416 | HP_0003418 | M54 | 1 | 1 | — | — | — | 1 |
| Spinal diseases | D013122 | — | M45-M49 | 1 | 1 | — | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Compartment syndromes | D003161 | — | T79.A0 | 1 | — | — | — | — | 1 |
| Acute pain | D059787 | — | R52 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ganglion cysts | D045888 | — | M67.4 | — | — | — | — | 3 | 3 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | — | — | — | 2 | 2 |
| Hallux valgus | D006215 | HP_0001822 | — | — | — | — | — | 2 | 2 |
| Bursitis | D002062 | EFO_1000941 | M71.9 | — | — | — | — | 2 | 2 |
| Tooth extraction | D014081 | — | — | — | — | — | — | 2 | 2 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 2 | 2 |
| Postherpetic neuralgia | D051474 | — | — | — | — | — | — | 2 | 2 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | — | — | — | — | 2 | 2 |
| Reflex sympathetic dystrophy | D012019 | EFO_1001147 | G90.5 | — | — | — | — | 2 | 2 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | — | — | — | — | 2 | 2 |
Show 63 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levonordefrin |
| INN | corbadrine |
| Description | Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 829-74-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL677 |
| ChEBI ID | 10304 |
| PubChem CID | 164739 |
| DrugBank | DB06707 |
| UNII ID | V008L6478D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (Q61619)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 505 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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307 adverse events reported
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