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Drug ReportsLevoleucovorin
Levoleucovorin
Khapzory, Levoleucovorin (levoleucovorin) is a small molecule pharmaceutical. Levoleucovorin was first approved as Fusilev on 2008-03-07.
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Trade Name
FDA
EMA
Khapzory, Levoleucovorin (discontinued: Fusilev, Khapzory, Levoleucovorin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levoleucovorin calcium
Tradename
Company
Number
Date
Products
FUSILEVAcrotech BiopharmaN-020140 DISCN2008-03-07
3 products, RLD
LEVOLEUCOVORIN CALCIUMAllerganN-208723 DISCN2016-09-29
1 products, RLD
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Levoleucovorin
Tradename
Company
Number
Date
Products
KHAPZORYAcrotech BiopharmaN-211226 RX2018-10-19
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
khapzoryNew Drug Application2024-12-12
levoleucovorinANDA2023-08-01
levoleucovorin calciumANDA2023-08-29
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
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FDA Information
Levoleucovorin, Khapzory, Acrotech Biopharma
115410122039-03-25DP
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AF: Detoxifying agents for antineoplastic treatment
— V03AF04: Calcium levofolinate
HCPCS
Code
Description
J0641
Injection, levoleucovorin, not otherwise specified, 0.5 mg
J0642
Injection, levoleucovorin (khapzory), 0.5 mg
Clinical
No data
Drug
General
Drug common nameLevoleucovorin
INNcalcium levofolinate
Description
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)c2c([nH]1)NC[C@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2C=O
Identifiers
PDB—
CAS-ID68538-85-2
RxCUI—
ChEMBL IDCHEMBL1908841
ChEBI ID63606
PubChem CID6006
DrugBankDB00650
UNII ID778XL6VBS8 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
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€
£
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Khapzory – Spectrum Pharmaceuticals
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Fusilev – Spectrum Pharmaceuticals
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Estimated US medical usage
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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