Levobunolol
Betagan, Levobunolol (levobunolol) is a small molecule pharmaceutical. Levobunolol was first approved as Betagan on 1985-12-19. It is used to treat open-angle glaucoma in the USA. The pharmaceutical is active against beta-3 adrenergic receptor, beta-2 adrenergic receptor, and beta-1 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Betagan, Levobunolol (discontinued: Akbeta, Betagan, Levobunolol)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| levobunolol hydrochloride | ANDA | 2024-07-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| open-angle glaucoma | EFO_0004190 | D005902 | H40.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | — | — | — | — | 1 | 1 |
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levobunolol |
| INN | levobunolol |
| Description | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrenergic antagonist. It is a propanolamine, a cyclic ketone and an aromatic ether. It is a conjugate acid of a levobunolol(1+). It derives from a hydride of a tetralin. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O |
Identifiers
| PDB | — |
| CAS-ID | 47141-42-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201237 |
| ChEBI ID | 6438 |
| PubChem CID | 39468 |
| DrugBank | DB01210 |
| UNII ID | G6317AOI7K (ChemIDplus, GSRS) |
Target
Agency Approved
ADRB3
ADRB3
ADRB2
ADRB2
ADRB1
ADRB1
Alternate
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Variants
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Financial
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Estimated US medical usage
Levobunolol
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Trends
PubMed Central
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Additional graphs summarizing 456 documents
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Safety
Black-box Warning
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Adverse Events
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210 adverse events reported
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