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AboutPricing
Drug ReportsLevetiracetam
Keppra(levetiracetam)
Keppra, Levetiracetam, Matever, Spritam (levetiracetam) is a small molecule pharmaceutical. Levetiracetam was first approved as Keppra on 1999-11-30. It is used to treat epilepsy, juvenile myoclonic epilepsy, partial epilepsies, and tonic-clonic epilepsy in the USA. It has been approved in Europe to treat epilepsy. The pharmaceutical is active against synaptic vesicle glycoprotein 2A.
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Drug
Target
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EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Keppra, Levetiracetam, Spritam (discontinued: Elepsia, Levetiracetam, Spritam)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levetiracetam
Tradename
Company
Number
Date
Products
SPRITAMAprecia PharmaceuticalsN-207958 RX2015-07-31
2 products, RLD, RS
LEVETIRACETAM IN SODIUM CHLORIDEHQ Specialty PharmaN-202543 RX2011-11-09
3 products, RLD, RS
KEPPRAUCBN-021035 RX1999-11-30
4 products, RLD
KEPPRAUCBN-021505 RX2003-07-15
1 products, RLD, RS
KEPPRAUCBN-021872 RX2006-07-31
1 products, RLD, RS
KEPPRA XRUCBN-022285 RX2008-09-12
2 products, RLD
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
elepsia xr 1000 mg elepsia xr 1500 mgNew Drug Application2024-03-25
keppraNew Drug Application2025-06-30
keppra keppra2009-05-11
keppra xr2009-05-21
levetiracetamANDA2025-09-24
levetiracetam erANDA2025-01-22
levetiracetam extended-releaseANDA2009-08-15
levetiracetam in sodium chlorideANDA2024-04-30
levetiracetam levetiracetamANDA2025-05-15
levetiracetam roweepraANDA2025-05-15
Show 2 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
epilepsyEFO_0000474D004827G40.9
juvenile myoclonic epilepsy—D020190G40.B
partial epilepsiesEFO_0004263D004828—
tonic-clonic epilepsyEFO_0007262D004830—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Levetiracetam, Spritam, Aprecia Pharms
93394892034-03-14DPU-1850
96690092034-03-14U-1850, U-2021, U-2022
111607862034-03-14DP
Levetiracetam, Keppra, Ucb Inc
88021422031-06-07DP
Levetiracetam, Keppra Xr, Ucb Inc
78581222028-09-17DP
Levetiracetam, Elepsia Xr, Tripoint
84311562027-10-31DP
84703672027-10-31DP
81633062027-09-03DP
84259382026-02-22DP
85357172026-02-22DP
ATC Codes
N: Nervous system drugs
— N03: Antiepileptics
— N03A: Antiepileptics
— N03AX: Other antiepileptics in atc
— N03AX14: Levetiracetam
HCPCS
Code
Description
J1953
Injection, levetiracetam, 10 mg
Clinical
Clinical Trials
294 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———4————4
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLevetiracetam
INNlevetiracetam
Description
Levetiracetam is a pyrrolidinone and carboxamide that is N-methylpyrrolidin-2-one in which one of the methyl hydrogens is replaced by an aminocarbonyl group, while another is replaced by an ethyl group (the S enantiomer). An anticonvulsant, it is used for the treatment of epilepsy in both human and veterinary medicine. It has a role as an anticonvulsant, an environmental contaminant and a xenobiotic.
Classification
Small molecule
Drug classnootropic agents (learning, cognitive enhancers), piracetam type
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@@H](C(N)=O)N1CCCC1=O
Identifiers
PDB—
CAS-ID102767-28-2
RxCUI—
ChEMBL IDCHEMBL1286
ChEBI ID6437
PubChem CID5284583
DrugBankDB01202
UNII ID44YRR34555 (ChemIDplus, GSRS)
Target
Agency Approved
SV2A
SV2A
Organism
Homo sapiens
Gene name
SV2A
Gene synonyms
KIAA0736
NCBI Gene ID
9900
Protein name
synaptic vesicle glycoprotein 2A
Protein synonyms
solute carrier family 22 member B1
Uniprot ID
Q9BVZ9
Mouse ortholog
Sv2a (64051)
synaptic vesicle glycoprotein 2A (Q9JIS5)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Levetiracetam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,197 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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80,071 adverse events reported
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