Levamisole
Ergamisol (levamisole) is a small molecule pharmaceutical. Levamisole was first approved as Ergamisol on 1990-06-18. It is used to treat colonic neoplasms in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levamisole hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ERGAMISOL | Johnson & Johnson | N-020035 DISCN | 1990-06-18 | 1 products |
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FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| colonic neoplasms | — | D003110 | C18 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0177 | Levamisole hydrochloride, oral, 50 mg |
Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | — | 1 | 1 | — | 2 |
| Syndrome | D013577 | — | — | — | — | 1 | 1 | — | 2 |
| Nephrosis | D009401 | — | — | — | — | 1 | 1 | — | 2 |
| Trichuriasis | D014257 | EFO_0007524 | — | — | — | — | 1 | — | 1 |
| Ascariasis | D001196 | EFO_0007154 | B77 | — | — | — | 1 | — | 1 |
| Ascaridiasis | D001198 | EFO_0007155 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | — | 4 | — | — | 4 |
| Covid-19 | D000086382 | — | — | — | 1 | 3 | — | — | 3 |
| Colonic neoplasms | D003110 | — | C18 | — | — | 3 | — | — | 3 |
| Loiasis | D008118 | — | B74.3 | — | 2 | 1 | — | — | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 1 | 1 | — | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | 1 | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | — | — | 1 | — | — | 1 |
| Cholangiocarcinoma | D018281 | — | C22.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | — | 4 | — | — | 1 | 5 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | — | 3 | — | — | 1 | 4 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | 3 | — | — | — | 3 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | 2 | — | — | — | 2 |
| Thrombosis | D013927 | — | — | — | 2 | — | — | — | 2 |
| Pancytopenia | D010198 | HP_0001876 | D61.81 | — | 2 | — | — | — | 2 |
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | 2 | — | — | — | 2 |
| Bone marrow failure disorders | D000080983 | — | — | — | 2 | — | — | — | 2 |
| Hemoglobinuria | D006456 | — | R82.3 | — | 2 | — | — | — | 2 |
| Urination disorders | D014555 | — | — | — | 2 | — | — | — | 2 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 1 | 1 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levamisole |
| INN | levamisole |
| Description | Levamisole is a 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. It has a role as an antinematodal drug, an antirheumatic drug, an immunomodulator, an immunological adjuvant and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is an enantiomer of a dexamisole. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1ccc([C@H]2CN3CCSC3=N2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 14769-73-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1454 |
| ChEBI ID | 6432 |
| PubChem CID | 26879 |
| DrugBank | DB00848 |
| UNII ID | 2880D3468G (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Levamisole
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Trends
PubMed Central
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Safety
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Adverse Events
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543 adverse events reported
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