Levamisole
Ergamisol (levamisole) is a small molecule pharmaceutical. Levamisole was first approved as Ergamisol on 1990-06-18. It is used to treat colonic neoplasms in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levamisole hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ERGAMISOL | Johnson & Johnson | N-020035 DISCN | 1990-06-18 | 1 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| colonic neoplasms | — | D003110 | C18 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| S0177 | Levamisole hydrochloride, oral, 50 mg |
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | 1 | 1 | 1 | — | 3 |
| Syndrome | D013577 | — | — | — | 1 | 1 | 1 | — | 3 |
| Nephrosis | D009401 | — | — | — | 1 | 1 | 1 | — | 3 |
| Trichuriasis | D014257 | EFO_0007524 | B79 | — | — | — | 1 | — | 1 |
| Ascariasis | D001196 | EFO_0007154 | B77 | — | — | — | 1 | — | 1 |
| Ascaridiasis | D001198 | EFO_0007155 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | — | 4 | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | — | — | 4 | — | — | 4 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 3 | — | — | 3 |
| Rectal neoplasms | D012004 | — | — | — | — | 2 | — | — | 2 |
| Loiasis | D008118 | — | B74.3 | — | 2 | 1 | — | — | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 1 | 1 | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
| Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 1 | 1 | — | — | 1 |
| Filariasis | D005368 | — | B74 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aplastic anemia | D000741 | — | D61.9 | — | 3 | — | — | 1 | 4 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 3 | — | — | — | 3 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | 3 | — | — | — | 3 |
| Proteinuria | D011507 | — | R80 | — | 2 | — | — | — | 2 |
| Thrombosis | D013927 | — | — | — | 2 | — | — | — | 2 |
| Pancytopenia | D010198 | — | D61.81 | — | 2 | — | — | — | 2 |
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | 2 | — | — | — | 2 |
| Bone marrow failure disorders | D000080983 | — | — | — | 2 | — | — | — | 2 |
| Hemoglobinuria | D006456 | — | R82.3 | — | 2 | — | — | — | 2 |
| Urination disorders | D014555 | — | — | — | 2 | — | — | — | 2 |
Show 12 more
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 1 | 1 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | — | — | — | 1 | 1 |
| Feasibility studies | D005240 | — | — | — | — | — | — | 1 | 1 |
| Mental health | D008603 | EFO_0003935 | — | — | — | — | — | 1 | 1 |
| Health behavior | D015438 | — | — | — | — | — | — | 1 | 1 |
| Life style | D008019 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Levamisole |
| INN | levamisole |
| Description | Levamisole is a 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. It has a role as an antinematodal drug, an antirheumatic drug, an immunomodulator, an immunological adjuvant and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is an enantiomer of a dexamisole. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1ccc([C@H]2CN3CCSC3=N2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 14769-73-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1454 |
| ChEBI ID | 6432 |
| PubChem CID | 26879 |
| DrugBank | DB00848 |
| UNII ID | 2880D3468G (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Levamisole
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 11,876 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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629 adverse events reported
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