Therapeutic Area | MeSH |
---|---|
infections | D007239 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
PREVYMIS | Merck Sharp & Dohme | N-209939 RX | 2017-11-08 | 2 products, RLD, RS |
PREVYMIS | Merck Sharp & Dohme | N-209940 RX | 2017-11-08 | 2 products, RLD, RS |
Expiration | Code | ||
---|---|---|---|
LETERMOVIR, PREVYMIS, MERCK SHARP DOHME | |||
2030-06-05 | ODE-423 | ||
2026-08-02 | D-189 | ||
2026-06-05 | I-916 | ||
2024-11-08 | ODE-165 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | 3 | 2 | 2 | — | 7 |
Neutropenia | D009503 | — | D70 | — | — | — | 2 | — | 2 |
Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Disease | D004194 | EFO_0000408 | R69 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hematopoietic stem cell transplantation | D018380 | — | — | — | 1 | — | — | 2 | 3 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | — | 2 | — | — | — | 2 |
Sezary syndrome | D012751 | — | C84.1 | — | 1 | — | — | — | 1 |
Prolymphocytic leukemia t-cell | D015461 | — | C91.6 | — | 1 | — | — | — | 1 |
T-cell lymphoma peripheral | D016411 | — | — | — | 1 | — | — | — | 1 |
Prolymphocytic leukemia b-cell | D054403 | — | C91.3 | — | 1 | — | — | — | 1 |
Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | — | — | — | 1 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
Primary myelofibrosis | D055728 | — | D47.4 | — | 1 | — | — | — | 1 |
Drug common name | Letermovir |
INN | letermovir |
Description | Letermovir (INN; brand name Prevymis) is an antiviral drug for the treatment of cytomegalovirus (CMV) infections. It has been tested in CMV infected patients with allogeneic stem cell transplants and may also be useful for other patients with a compromised immune system such as those with organ transplants or HIV infections. The drug was initially developed by the anti-infective division at Bayer, which became AiCuris Anti-infective Cures AG through a spin-out and progressed the development to end of Phase 2 before the project was sold to Merck & Co for Phase 3 development and approval.
|
Classification | Small molecule |
Drug class | antivirals |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 |
PDB | — |
CAS-ID | 917389-32-3 |
RxCUI | — |
ChEMBL ID | CHEMBL1241951 |
ChEBI ID | — |
PubChem CID | 45138674 |
DrugBank | DB12070 |
UNII ID | 1H09Y5WO1F (ChemIDplus, GSRS) |