Lestaurtinib
Lestaurtinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against receptor-type tyrosine-protein kinase FLT3.
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Commercial
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | 4 | 1 | — | 1 | 6 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | — | 1 | — | 1 | 2 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | — | 1 | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 3 | — | — | 1 | 4 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 3 | — | — | — | 3 |
| Essential thrombocythemia | D013920 | — | D47.3 | 1 | 2 | — | — | — | 2 |
| Polycythemia vera | D011087 | — | D45 | 1 | 2 | — | — | — | 2 |
| Thrombocytosis | D013922 | — | D75.83 | 1 | 2 | — | — | — | 2 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | 1 | 2 | — | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | 2 | — | — | — | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lestaurtinib |
| INN | lestaurtinib |
| Description | LSM-1231 is an indolocarbazole. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O |
Identifiers
| PDB | — |
| CAS-ID | 111358-88-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL603469 |
| ChEBI ID | — |
| PubChem CID | 126565 |
| DrugBank | — |
| UNII ID | DO989GC5D1 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
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257 adverse events reported
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