Zurampic(lesinurad)
Duzallo, Zurampic (lesinurad) is a small molecule pharmaceutical. Lesinurad was first approved as Zurampic on 2015-12-22. It is used to treat hyperuricemia in the USA. It has been approved in Europe to treat gout and hyperuricemia. It is known to target solute carrier family 22 member 12.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol
+
Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUZALLO | Ironwood Pharmaceuticals | N-209203 DISCN | 2017-08-18 | 2 products, RLD |
Hide discontinued
Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZURAMPIC | Ironwood Pharmaceuticals | N-207988 DISCN | 2015-12-22 | 1 products, RLD |
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperuricemia | HP_0002149 | D033461 | — |
| gout | EFO_0004274 | D006073 | M10 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Allopurinol / Lesinurad, Duzallo, Ironwood Pharms Inc | |||
| 8546436 | 2032-02-29 | DS, DP | |
| 9956205 | 2031-12-28 | U-2104, U-2311 | |
| 9216179 | 2031-08-01 | U-1806, U-2104 | |
| 8357713 | 2029-12-22 | DP | U-1801, U-1802, U-1803, U-2104 |
| 8084483 | 2029-08-17 | U-1801, U-2104 | |
| 8546437 | 2029-04-29 | U-1803, U-2104 | |
| 8283369 | 2028-11-26 | U-1802, U-1804, U-2104 | |
| 10183012 | 2028-11-26 | U-2104, U-2311 | |
| 8003681 | 2025-08-25 | DP | |
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 3 | 1 | 7 | 1 | 1 | 13 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperuricemia | D033461 | HP_0002149 | — | — | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Lesinurad |
| INN | lesinurad |
| Description | Lesinurad (brand name Zurampic) is a urate transporter inhibitor for treating high blood uric acid levels associated with gout. It is recommended only as an adjuvant with either allopurinol or febuxostat when these medications are not sufficient.
|
| Classification | Small molecule |
| Drug class | urate transporter inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |
Identifiers
| PDB | — |
| CAS-ID | 878672-00-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105720 |
| ChEBI ID | — |
| PubChem CID | 56928182 |
| DrugBank | DB11560 |
| UNII ID | 09ERP08I3W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC22A12
SLC22A12
Organism
Homo sapiens
Gene name
SLC22A12
Gene synonyms
OATL4, URAT1
NCBI Gene ID
Protein name
solute carrier family 22 member 12
Protein synonyms
Organic anion transporter 4-like protein, Renal-specific transporter, RST, solute carrier family 22 (organic anion/cation transporter), member 12, solute carrier family 22 (organic anion/urate transporter), member 12, URAT1, Urate anion exchanger 1, urate anion transporter 1, urate transporter 1, Urate:anion antiporter SLC22A12
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Lesinurad – Ironwood Pharmaceuticals
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Zurampic – Ironwood Pharmaceuticals
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 460 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
83 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use