Zurampic(lesinurad)
Duzallo, Zurampic (lesinurad) is a small molecule pharmaceutical. Lesinurad was first approved as Zurampic on 2015-12-22. It is used to treat hyperuricemia in the USA. It has been approved in Europe to treat gout and hyperuricemia. It is known to target solute carrier family 22 member 12.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol
+
Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUZALLO | Ironwood Pharmaceuticals | N-209203 DISCN | 2017-08-18 | 2 products, RLD |
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Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZURAMPIC | Ironwood Pharmaceuticals | N-207988 DISCN | 2015-12-22 | 1 products, RLD |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperuricemia | HP_0002149 | D033461 | — |
| gout | EFO_0004274 | D006073 | M10 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Allopurinol / Lesinurad, Duzallo, Ironwood Pharms Inc | |||
| 8546436 | 2032-02-29 | DS, DP | |
| 9956205 | 2031-12-28 | U-2104, U-2311 | |
| 9216179 | 2031-08-01 | U-1806, U-2104 | |
| 8357713 | 2029-12-22 | DP | U-1801, U-1802, U-1803, U-2104 |
| 8084483 | 2029-08-17 | U-1801, U-2104 | |
| 8546437 | 2029-04-29 | U-1803, U-2104 | |
| 8283369 | 2028-11-26 | U-1802, U-1804, U-2104 | |
| 10183012 | 2028-11-26 | U-2104, U-2311 | |
| 8003681 | 2025-08-25 | DP | |
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 3 | 1 | 7 | 1 | 1 | 13 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperuricemia | D033461 | HP_0002149 | — | — | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lesinurad |
| INN | lesinurad |
| Description | Lesinurad (brand name Zurampic) is a urate transporter inhibitor for treating high blood uric acid levels associated with gout. It is recommended only as an adjuvant with either allopurinol or febuxostat when these medications are not sufficient.
|
| Classification | Small molecule |
| Drug class | urate transporter inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |
Identifiers
| PDB | — |
| CAS-ID | 878672-00-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105720 |
| ChEBI ID | — |
| PubChem CID | 56928182 |
| DrugBank | DB11560 |
| UNII ID | 09ERP08I3W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC22A12
SLC22A12
Organism
Homo sapiens
Gene name
SLC22A12
Gene synonyms
OATL4, URAT1
NCBI Gene ID
Protein name
solute carrier family 22 member 12
Protein synonyms
Organic anion transporter 4-like protein, Renal-specific transporter, RST, solute carrier family 22 (organic anion/cation transporter), member 12, solute carrier family 22 (organic anion/urate transporter), member 12, URAT1, Urate anion exchanger 1, urate anion transporter 1, urate transporter 1, Urate:anion antiporter SLC22A12
Uniprot ID
Mouse ortholog
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—
Variants
No data
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Zurampic – Ironwood Pharmaceuticals
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Lesinurad – Ironwood Pharmaceuticals
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 465 documents
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Safety
Black-box Warning
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Adverse Events
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83 adverse events reported
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