Lepirudin
Refludan (lepirudin) is a protein pharmaceutical. Lepirudin was first approved as Refludan on 1997-03-13. It is used to treat thrombocytopenia, thromboembolism, and unstable angina in the USA. It has been approved in Europe to treat thrombocytopenia and thromboembolism. The pharmaceutical is active against prothrombin.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J1945 | Injection, lepirudin, 50 mg |
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | 2 | 1 | 3 |
| Thrombosis | D013927 | — | — | — | 1 | — | 1 | — | 2 |
| Critical illness | D016638 | — | — | — | — | — | 1 | — | 1 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lepirudin |
| INN | lepirudin |
| Description | Hirudin variant-1 (Lepirudin) |
| Classification | Protein |
| Drug class | anticoagulants (hirudin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >2ZFF:H|Thrombin heavy chain
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDQFGE
>2ZFF:L|Thrombin light chain
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR |
Identifiers
| PDB | 1H8D, 1H8I, 1W7G, 2JOO, 2PW8, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3D49, 3DHK, 3DT0, 3DUX, 3EGK, 3EQ0, 3LDX, 3UTU, 4AX9, 4BAH, 4BAK, 4BAM, 4BAN, 4BAQ, 4LXB, 4MLF, 4YES |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201666 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00001 |
| UNII ID | Y43GF64R34 (ChemIDplus, GSRS) |
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Safety
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321 adverse events reported
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