Lenograstim
Lenograstim is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target granulocyte colony-stimulating factor receptor and macrophage colony-stimulating factor 1 receptor.
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1740 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 68 | 190 | 38 | 12 | 27 | 303 |
| Leukemia | D007938 | — | C95 | 84 | 175 | 44 | 9 | 27 | 292 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 65 | 127 | 34 | 3 | 14 | 213 |
| Multiple myeloma | D009101 | — | C90.0 | 42 | 108 | 23 | 3 | 18 | 176 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 44 | 101 | 20 | 4 | 13 | 161 |
| Myelodysplastic syndromes | D009190 | — | D46 | 49 | 95 | 19 | 3 | 13 | 152 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 33 | 71 | 38 | 14 | 8 | 147 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 42 | 85 | 16 | 9 | 12 | 145 |
| Neoplasms | D009369 | — | C80 | 55 | 43 | 13 | 4 | 13 | 115 |
| Myeloid leukemia | D007951 | — | C92 | 29 | 64 | 21 | 1 | 9 | 108 |
Show 59 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin disease | D006689 | — | C81 | 22 | 60 | 12 | — | 4 | 87 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 28 | 44 | 11 | — | 6 | 75 |
| Sarcoma | D012509 | — | — | 21 | 41 | 10 | — | 3 | 67 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 25 | 37 | 4 | — | 7 | 65 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 22 | 31 | 4 | — | 7 | 58 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 23 | 34 | 3 | — | 5 | 56 |
| Follicular lymphoma | D008224 | — | C82 | 23 | 28 | 5 | — | 5 | 52 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 12 | 36 | 4 | — | 3 | 50 |
| Central nervous system neoplasms | D016543 | — | — | 17 | 30 | 5 | — | 2 | 50 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 17 | 17 | 1 | — | 5 | 35 |
Show 139 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 7 | 8 | — | — | 2 | 14 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 7 | — | — | 4 | 14 |
| Blast crisis | D001752 | — | — | 7 | 6 | — | — | 1 | 13 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.03 | 6 | 10 | — | — | 1 | 13 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 9 | — | — | 1 | 11 |
| Fallopian tube neoplasms | D005185 | — | — | 6 | 4 | — | — | 1 | 10 |
| T-cell lymphoma | D016399 | — | — | 2 | 7 | — | — | 1 | 10 |
| Colorectal neoplasms | D015179 | — | — | 4 | 6 | — | — | 1 | 9 |
| Primitive neuroectodermal tumors peripheral | D018241 | — | — | 5 | 4 | — | — | 1 | 9 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 2 | 6 | — | — | 2 | 9 |
Show 195 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hairy cell leukemia | D007943 | — | C91.4 | 4 | — | — | — | 3 | 7 |
| Pinealoma | D010871 | — | — | 3 | — | — | — | — | 3 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | 2 | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | — | — | — | 1 | 3 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 2 | — | — | — | 1 | 3 |
| Aids-related complex | D000386 | EFO_0007137 | B20 | 1 | — | — | — | 2 | 3 |
| Neoplasms by histologic type | D009370 | — | — | 2 | — | — | — | — | 2 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 2 | — | — | — | — | 2 |
| Vasculitis | D014657 | EFO_0006803 | M31 | 1 | — | — | — | 1 | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | — | — | — | 1 | 2 |
Show 39 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | — | 2 | 2 |
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | — | — | — | — | 2 | 2 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | — | — | — | 2 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | — | 2 | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 2 | 2 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | — | — | — | 1 | 1 |
| Abnormal karyotype | D059786 | — | — | — | — | — | — | 1 | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Nephritis | D009393 | — | N05 | — | — | — | — | 1 | 1 |
| Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 1 | 1 |
Show 31 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lenograstim |
| INN | lenograstim |
| Description | Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator. It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
|
| Classification | Protein |
| Drug class | colony-stimulating factors: granulocyte colony-stimulating factors (G-CSF) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109128 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6WS4C399GB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CSF3R
CSF3R
Organism
Homo sapiens
Gene name
CSF3R
Gene synonyms
GCSFR
NCBI Gene ID
Protein name
granulocyte colony-stimulating factor receptor
Protein synonyms
CD114, CD114 antigen, colony stimulating factor 3 receptor (granulocyte), G-CSF receptor, G-CSF-R
Uniprot ID
Mouse ortholog
Csf3r (12986)
granulocyte colony-stimulating factor receptor (P40223)
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,137 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,356 adverse events reported
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