Lenograstim
Lenograstim is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target granulocyte colony-stimulating factor receptor and macrophage colony-stimulating factor 1 receptor.
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1545 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 85 | 227 | 48 | 6 | 26 | 352 |
| Leukemia | D007938 | — | C95 | 106 | 213 | 52 | 5 | 30 | 350 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 49 | 103 | 29 | 1 | 12 | 170 |
| Multiple myeloma | D009101 | — | C90.0 | 39 | 94 | 23 | 2 | 16 | 156 |
| Myelodysplastic syndromes | D009190 | — | D46 | 47 | 91 | 18 | 2 | 12 | 143 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 36 | 93 | 18 | 3 | 10 | 139 |
| Plasma cell neoplasms | D054219 | — | — | 34 | 80 | 23 | 2 | 13 | 138 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 32 | 63 | 38 | 12 | 8 | 136 |
| Neoplasms | D009369 | — | C80 | 59 | 56 | 14 | 1 | 10 | 123 |
| Preleukemia | D011289 | — | — | 35 | 69 | 13 | 1 | 9 | 107 |
Show 53 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia | D007951 | — | C92 | 49 | 107 | 29 | — | 10 | 170 |
| Hodgkin disease | D006689 | — | C81 | 13 | 47 | 12 | — | 3 | 66 |
| Sarcoma | D012509 | — | — | 19 | 39 | 11 | — | 3 | 66 |
| Recurrence | D012008 | — | — | 28 | 33 | 4 | — | 3 | 57 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 22 | 30 | 4 | — | 7 | 57 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 13 | 35 | 4 | — | 3 | 50 |
| Central nervous system neoplasms | D016543 | — | — | 17 | 30 | 5 | — | 2 | 50 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 23 | 29 | 5 | — | 3 | 49 |
| Nervous system neoplasms | D009423 | — | — | 16 | 29 | 5 | — | 1 | 47 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 19 | 26 | 6 | — | 4 | 45 |
Show 130 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 7 | 7 | — | — | 3 | 14 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 4 | 6 | — | — | 4 | 14 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 6 | 11 | — | — | — | 12 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 6 | 6 | — | — | 1 | 11 |
| Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 5 | 7 | — | — | 2 | 11 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.03 | 5 | 8 | — | — | 1 | 11 |
| Fanconi syndrome | D005198 | — | — | 5 | 8 | — | — | 1 | 11 |
| Pancytopenia | D010198 | — | D61.81 | 1 | 8 | — | — | 2 | 10 |
| Bone marrow failure disorders | D000080983 | — | — | 1 | 8 | — | — | 1 | 9 |
| Acute disease | D000208 | — | — | 6 | 5 | — | — | 2 | 9 |
Show 185 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | 3 | 4 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | — | — | — | 1 | 3 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 2 | — | — | — | 1 | 3 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 2 | — | — | — | — | 2 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | 2 | — | — | — | — | 2 |
| Neoplasms by histologic type | D009370 | — | — | 2 | — | — | — | — | 2 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 2 | — | — | — | — | 2 |
| Vasculitis | D014657 | EFO_0006803 | M31 | 1 | — | — | — | 1 | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | — | — | — | 1 | 2 |
| Aids-related complex | D000386 | EFO_0007137 | B20 | 1 | — | — | — | 1 | 2 |
Show 42 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | — | 2 | 2 |
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | — | — | — | — | 2 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | — | 2 | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 2 | 2 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | — | — | — | 1 | 1 |
| Abnormal karyotype | D059786 | — | — | — | — | — | — | 1 | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Nephritis | D009393 | — | N05 | — | — | — | — | 1 | 1 |
| Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 1 | 1 |
| Arteritis | D001167 | EFO_0009011 | I77.6 | — | — | — | — | 1 | 1 |
Show 33 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lenograstim |
| INN | lenograstim |
| Description | Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator. It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
|
| Classification | Protein |
| Drug class | colony-stimulating factors: granulocyte colony-stimulating factors (G-CSF) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109128 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6WS4C399GB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CSF3R
CSF3R
Organism
Homo sapiens
Gene name
CSF3R
Gene synonyms
GCSFR
NCBI Gene ID
Protein name
granulocyte colony-stimulating factor receptor
Protein synonyms
CD114, CD114 antigen, colony stimulating factor 3 receptor (granulocyte), G-CSF receptor, G-CSF-R
Uniprot ID
Mouse ortholog
Csf3r (12986)
granulocyte colony-stimulating factor receptor (P40223)
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,202 adverse events reported
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