Lenograstim
Lenograstim is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target granulocyte colony-stimulating factor receptor and macrophage colony-stimulating factor 1 receptor.
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Clinical Trials
1500 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 46 | 133 | 27 | 3 | 17 | 207 |
| Leukemia | D007938 | — | C95 | 50 | 103 | 16 | 3 | 13 | 164 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 42 | 74 | 23 | 1 | 9 | 130 |
| Myelodysplastic syndromes | D009190 | — | D46 | 41 | 78 | 16 | 1 | 12 | 125 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 30 | 60 | 32 | 11 | 8 | 125 |
| Multiple myeloma | D009101 | — | C90.0 | 26 | 63 | 13 | 1 | 12 | 101 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 16 | 48 | 7 | 2 | 10 | 76 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 19 | 46 | 11 | 2 | 7 | 73 |
| Neoplasms | D009369 | — | C80 | 33 | 19 | 7 | 1 | 3 | 58 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 22 | 21 | 11 | 1 | 3 | 55 |
Show 29 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 16 | 35 | 10 | — | 2 | 58 |
| Hodgkin disease | D006689 | — | C81 | 11 | 37 | 8 | — | 3 | 52 |
| Central nervous system neoplasms | D016543 | — | — | 17 | 28 | 5 | — | 1 | 47 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 22 | 27 | 3 | — | 3 | 45 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 14 | 19 | 3 | — | 4 | 33 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 9 | 16 | 2 | — | 5 | 29 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 5 | 20 | 3 | — | 2 | 28 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 17 | 3 | — | 4 | 25 |
| Follicular lymphoma | D008224 | — | C82 | 10 | 14 | 3 | — | 3 | 24 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 9 | 10 | 2 | — | 5 | 24 |
Show 89 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | — | C83.1 | 8 | 15 | — | — | 3 | 22 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 5 | 9 | — | — | 2 | 15 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 5 | — | — | 4 | 12 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 6 | 6 | — | — | 1 | 11 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 6 | 9 | — | — | — | 11 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | 5 | 8 | — | — | 1 | 11 |
| Fallopian tube neoplasms | D005185 | — | — | 6 | 3 | — | — | 1 | 9 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 3 | 3 | — | — | 3 | 8 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 3 | 4 | — | — | 2 | 8 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 4 | 2 | — | — | 2 | 8 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | 3 | 4 |
| Astrocytoma | D001254 | EFO_0000271 | — | 3 | — | — | — | — | 3 |
| Primitive neuroectodermal tumors | D018242 | — | — | 2 | — | — | — | 1 | 3 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | 2 | 3 |
| Neoplasms by histologic type | D009370 | — | — | 2 | — | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 2 | — | — | — | — | 2 |
| Rhabdoid tumor | D018335 | — | — | 2 | — | — | — | — | 2 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 2 | — | — | — | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | 1 | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | — | — | — | 1 | 2 |
Show 28 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | — | — | — | — | 2 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | — | 2 | 2 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | — | — | — | 1 | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 1 | 1 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | — | — | — | — | 1 | 1 |
| Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | — | — | — | 1 | 1 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | — | — | — | 1 | 1 |
| Churg-strauss syndrome | D015267 | EFO_0007208 | M30.1 | — | — | — | — | 1 | 1 |
| Polyarteritis nodosa | D010488 | EFO_0009012 | M30.0 | — | — | — | — | 1 | 1 |
Show 13 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lenograstim |
| INN | lenograstim |
| Description | Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator. It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
|
| Classification | Protein |
| Drug class | colony-stimulating factors: granulocyte colony-stimulating factors (G-CSF) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109128 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6WS4C399GB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CSF3R
CSF3R
Organism
Homo sapiens
Gene name
CSF3R
Gene synonyms
GCSFR
NCBI Gene ID
Protein name
granulocyte colony-stimulating factor receptor
Protein synonyms
CD114, CD114 antigen, colony stimulating factor 3 receptor (granulocyte), G-CSF receptor, G-CSF-R
Uniprot ID
Mouse ortholog
Csf3r (12986)
granulocyte colony-stimulating factor receptor (P40223)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 922 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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982 adverse events reported
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