Revlimid(lenalidomide)
Revlimid (lenalidomide) is a small molecule pharmaceutical. Lenalidomide was first approved as Revlimid on 2005-12-27. It is used to treat b-cell lymphoma marginal zone, follicular lymphoma, mantle-cell lymphoma, multiple myeloma, and myelodysplastic syndromes in the USA. It has been approved in Europe to treat follicular lymphoma, mantle-cell lymphoma, multiple myeloma, and myelodysplastic syndromes. It is known to target protein cereblon.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Revlimid (generic drugs available since 2021-05-21)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lenalidomide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| REVLIMID | Bristol Myers Squibb | N-021880 RX | 2005-12-27 | 6 products, RLD |
Labels
FDA
EMA
No data
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
LENALIDOMIDE, REVLIMID, BRISTOL MYERS SQUIBB | |||
| 2026-05-28 | ODE-241, ODE-245 | ||
| 2024-02-22 | ODE-131 | ||
HCPCS
No data
Clinical
Clinical Trials
1166 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 141 | 274 | 103 | 12 | 40 | 499 |
| Myelodysplastic syndromes | D009190 | — | D46 | 20 | 35 | 3 | 1 | 10 | 64 |
| Follicular lymphoma | D008224 | — | C82 | 32 | 35 | 9 | 1 | 3 | 62 |
| T-cell lymphoma peripheral | D016411 | — | — | 9 | 10 | — | 1 | — | 16 |
| B-cell lymphoma | D016393 | — | — | 6 | 8 | 1 | 1 | — | 11 |
| T-cell lymphoma | D016399 | — | — | 3 | 3 | — | 1 | — | 6 |
| Hematologic neoplasms | D019337 | — | — | 1 | 3 | — | 1 | — | 4 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 1 | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | 1 | — | 3 |
| Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | — | — | — | 1 | — | 1 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 39 | 52 | 3 | — | 2 | 80 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 33 | 47 | 9 | — | 6 | 76 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 30 | 33 | 4 | — | 4 | 59 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 21 | 25 | 3 | — | 4 | 44 |
| Lymphoma | D008223 | — | C85.9 | 16 | 27 | 4 | — | 2 | 38 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 20 | 17 | 1 | — | 3 | 37 |
| Neoplasms | D009369 | — | C80 | 20 | 10 | 1 | — | — | 25 |
| Plasma cell neoplasms | D054219 | — | — | 7 | 14 | 1 | — | 2 | 19 |
| Smoldering multiple myeloma | D000075122 | — | — | 3 | 9 | 2 | — | — | 13 |
| Prostatic neoplasms | D011471 | — | C61 | 5 | 7 | 1 | — | — | 10 |
Show 12 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 14 | 11 | — | — | — | 19 |
| Leukemia | D007938 | — | C95 | 6 | 15 | — | — | 1 | 19 |
| Hodgkin disease | D006689 | — | C81 | 13 | 10 | — | — | — | 18 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 8 | 8 | — | — | — | 13 |
| Burkitt lymphoma | D002051 | — | C83.7 | 11 | 6 | — | — | — | 12 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 8 | 7 | — | — | — | 10 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 7 | 4 | — | — | — | 9 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 6 | 4 | — | — | — | 9 |
| Plasma cell leukemia | D007952 | — | C90.1 | 3 | 5 | — | — | 1 | 8 |
| Intraocular lymphoma | D064090 | — | — | 5 | 4 | — | — | — | 7 |
Show 85 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroblastoma | D009447 | EFO_0000621 | — | 3 | — | — | — | — | 3 |
| Colonic neoplasms | D003110 | — | C18 | 2 | — | — | — | — | 2 |
| Rectal neoplasms | D012004 | — | — | 2 | — | — | — | — | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 2 | — | — | — | — | 2 |
| Promyelocytic leukemia acute | D015473 | — | C92.4 | 2 | — | — | — | — | 2 |
| Urethral neoplasms | D014523 | EFO_0003846 | — | 1 | — | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Tongue neoplasms | D014062 | EFO_0003871 | C02.9 | 1 | — | — | — | — | 1 |
Show 26 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Residual neoplasm | D018365 | — | — | — | — | — | — | 1 | 1 |
| Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
| Cutaneous lupus erythematosus | D008178 | EFO_0003834 | L93.1 | — | — | — | — | 1 | 1 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 1 | 1 |
| Patient satisfaction | D017060 | — | — | — | — | — | — | 1 | 1 |
| Personal satisfaction | D010549 | — | — | — | — | — | — | 1 | 1 |
| Patient preference | D057240 | — | — | — | — | — | — | 1 | 1 |
| Progression-free survival | D000077982 | — | — | — | — | — | — | 1 | 1 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | — | — | — | 1 | 1 |
| Oral ulcer | D019226 | HP_0000155 | — | — | — | — | — | 1 | 1 |
Show 2 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Lenalidomide |
| INN | lenalidomide |
| Description | Lenalidomide is a dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. It inhibits the secretion of TNF-alpha and has a role as an angiogenesis inhibitor, an antineoplastic agent and an immunomodulator. It is a member of isoindoles, a dicarboximide, a member of piperidones and an aromatic amine. Lenalidomide is a thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. |
| Classification | Small molecule |
| Drug class | thalidomide derivatives; narcotic agonists/antagonists (normorphine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O |
Identifiers
| PDB | — |
| CAS-ID | 191732-72-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL848 |
| ChEBI ID | 63791 |
| PubChem CID | 216326 |
| DrugBank | DB00480 |
| UNII ID | F0P408N6V4 (ChemIDplus, GSRS) |
Target
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Revlimid – Bristol Myers Squibb
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Revlimid – Celgene
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 20,381 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
285,393 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use