Brand Name | Status | Last Update |
---|---|---|
arava | New Drug Application | 2025-06-04 |
inflatherm | ANDA | 2022-12-07 |
lefluniclo | unapproved drug other | 2023-03-29 |
leflunomide | ANDA | 2025-06-27 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
rheumatic diseases | — | D012216 | M79.0 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Arthritis | D001168 | EFO_0005856 | M05-M14 | 2 | 9 | 24 | 21 | 17 | 70 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | 8 | 22 | 18 | 14 | 62 |
Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | 3 | — | 1 | 3 | 8 |
Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | 1 | — | 1 | 2 | 3 | 7 |
Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | 2 | 1 | 1 | 1 | 4 |
Immunoglobulin g4-related disease | D000077733 | — | D89.84 | — | — | — | 1 | 1 | 2 |
Renal insufficiency | D051437 | — | N19 | — | — | — | 1 | 1 | 2 |
Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 1 | — | 1 | — | 2 |
Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | — | 1 |
Glomerulonephritis | D005921 | — | N05 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Covid-19 | D000086382 | — | U07.1 | 2 | 1 | 1 | — | 1 | 4 |
Nephritis | D009393 | — | N05 | — | 2 | 2 | — | 1 | 4 |
Lupus nephritis | D008181 | EFO_0005761 | — | — | 1 | 2 | — | 1 | 3 |
Virus diseases | D014777 | — | B34 | — | — | 1 | — | 1 | 2 |
Central nervous system neoplasms | D016543 | — | — | — | 1 | 1 | — | — | 2 |
Nervous system neoplasms | D009423 | — | — | — | 1 | 1 | — | — | 2 |
Inflammation | D007249 | MP_0001845 | — | — | 1 | 1 | — | 1 | 2 |
Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | — | 1 | — | — | 1 |
Polymyalgia rheumatica | D011111 | EFO_0008518 | M35.3 | — | — | 1 | — | — | 1 |
Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple myeloma | D009101 | — | C90.0 | 2 | 4 | — | — | — | 5 |
Plasma cell neoplasms | D054219 | — | — | 2 | 4 | — | — | — | 5 |
Neoplasms | D009369 | — | C80 | 2 | 2 | — | — | — | 3 |
Smoldering multiple myeloma | D000075122 | — | — | 1 | 2 | — | — | — | 3 |
Hematologic neoplasms | D019337 | — | — | 2 | 1 | — | — | — | 2 |
Iga vasculitis | D011695 | EFO_1000965 | D69.0 | — | 1 | — | — | 1 | 2 |
Purpura | D011693 | HP_0000979 | D69.2 | — | 1 | — | — | 1 | 2 |
Viremia | D014766 | — | B34.9 | — | 1 | — | — | 1 | 2 |
Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 2 |
Syndrome | D013577 | — | — | 1 | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
Graft vs host disease | D006086 | — | D89.81 | 2 | — | — | — | — | 2 |
Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | 1 | — | — | — | — | 1 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | — | 1 |
Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | — | 1 |
Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | — | — | — | 4 | 4 |
Herpesviridae infections | D006566 | EFO_0007309 | B00.4 | — | — | — | — | 2 | 2 |
Arteritis | D001167 | EFO_0009011 | I77.6 | — | — | — | — | 2 | 2 |
Takayasu arteritis | D013625 | EFO_1001857 | M31.4 | — | — | — | — | 2 | 2 |
Aortic arch syndromes | D001015 | — | — | — | — | — | — | 2 | 2 |
Osteomyelitis | D010019 | EFO_0003102 | M86 | — | — | — | — | 1 | 1 |
Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
Kidney transplantation | D016030 | — | — | — | — | — | — | 1 | 1 |
Communicable diseases | D003141 | — | — | — | — | — | — | 1 | 1 |
Vasculitis | D014657 | EFO_0006803 | M31 | — | — | — | — | 1 | 1 |
Drug common name | Leflunomide |
INN | leflunomide |
Description | Leflunomide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. It has a role as a non-steroidal anti-inflammatory drug, an antineoplastic agent, an antiparasitic agent, an EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor, a hepatotoxic agent, a prodrug, a pyrimidine synthesis inhibitor, an immunosuppressive agent, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and a tyrosine kinase inhibitor. It is a monocarboxylic acid amide, a member of isoxazoles and a member of (trifluoromethyl)benzenes. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 |
PDB | — |
CAS-ID | 75706-12-6 |
RxCUI | — |
ChEMBL ID | CHEMBL960 |
ChEBI ID | 6402 |
PubChem CID | 3899 |
DrugBank | DB01097 |
UNII ID | G162GK9U4W (ChemIDplus, GSRS) |