Ebglyss(lebrikizumab)
Ebglyss (lebrikizumab) is an antibody pharmaceutical. Lebrikizumab was first approved as Ebglyss on 2023-11-16. It is used to treat atopic dermatitis in the USA. It has been approved in Europe to treat atopic dermatitis.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Ebglyss
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ebglyss | Biologic Licensing Application | 2025-02-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| atopic dermatitis | EFO_0000274 | D003876 | L20 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | 4 | 1 | 1 | 6 |
| Eczema | D004485 | — | L30.9 | — | — | 4 | 1 | 1 | 6 |
| Dermatitis | D003872 | — | L30.9 | — | — | 4 | 1 | 1 | 6 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Skin manifestations | D012877 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lebrikizumab |
| INN | lebrikizumab |
| Description | Lebrikizumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >4I77:H|Lebrikizumab heavy chain
QVTLRESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVL
TMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESK
>4I77:L|Lebrikizumab light chain
DIVMTQSPDSLSVSLGERATINCRASKSVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTIS
SLQAEDVAVYYCQQNNEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQS
GNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 4I77 |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743035 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11914 |
| UNII ID | U9JLP7V031 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 1,299 documents
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Safety
Black-box Warning
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Adverse Events
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81 adverse events reported
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