Laropiprant
Pelzont, Tredaptive, Trevaclyn (laropiprant) is a small molecule pharmaceutical. Laropiprant was first approved as Trevaclyn on 2008-07-03. It has been approved in Europe to treat dyslipidemias. It is known to target prostaglandin D2 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
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Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dyslipidemias | D050171 | HP_0003119 | — | 2 | 1 | 8 | 1 | 1 | 13 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | 1 | — | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 1 | 1 | — | 2 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | 1 | — | 1 |
| Syndrome | D013577 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypercholesterolemia | D006937 | HP_0003124 | — | 3 | 1 | 11 | — | 1 | 16 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 1 | — | 6 | — | — | 7 |
| Hyperlipoproteinemias | D006951 | HP_0010980 | — | — | — | 6 | — | — | 6 |
| Hyperlipoproteinemia type v | D006954 | Orphanet_70470 | E78.3 | 1 | — | 3 | — | — | 4 |
| Familial combined hyperlipidemia | D006950 | EFO_0000492 | E78.49 | 1 | — | 3 | — | — | 4 |
| Lipidoses | D008064 | — | E75.6 | — | — | 3 | — | — | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 2 | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | 1 | — | — | 2 |
| Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | 1 | — | 1 | — | — | 2 |
| Coronary disease | D003327 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
| Flushing | D005483 | — | R23.2 | — | 1 | — | — | — | 1 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Lipid metabolism disorders | D052439 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Laropiprant |
| INN | laropiprant |
| Description | Laropiprant (INN) was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin.
|
| Classification | Small molecule |
| Drug class | prostaglandin receptor antagonists, non prostinoid structure |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 |
Identifiers
| PDB | — |
| CAS-ID | 571170-77-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL426559 |
| ChEBI ID | — |
| PubChem CID | 11948701 |
| DrugBank | DB11629 |
| UNII ID | G7N11T8O78 (ChemIDplus, GSRS) |
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Safety
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125 adverse events reported
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