Lampalizumab
Lampalizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against complement factor D.
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Clinical Trials
102 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 1 | — | 1 | — | 3 |
| Aplastic anemia | D000741 | — | D61.9 | 1 | — | — | 1 | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 2 | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
| Proteinuria | D011507 | — | R80 | — | — | — | 1 | — | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | — | 1 | — | 1 |
| Metabolic bone diseases | D001851 | — | — | — | — | — | 1 | — | 1 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | — | — | — | 1 | — | 1 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 6 | 10 | 4 | — | — | 18 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 9 | 7 | 1 | — | — | 15 |
| Leukemia | D007938 | — | C95 | 5 | 7 | 1 | — | — | 10 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | 4 | 4 | — | — | 8 |
| Geographic atrophy | D057092 | — | — | 1 | 3 | 3 | — | — | 7 |
| Atrophy | D001284 | — | — | 1 | 3 | 3 | — | — | 7 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 2 | 1 | — | — | 6 |
| Myeloid leukemia | D007951 | — | C92 | 4 | 3 | 1 | — | — | 6 |
| Carcinoma | D002277 | — | C80.0 | 1 | 4 | 1 | — | — | 6 |
| Syndrome | D013577 | — | — | 1 | 4 | 1 | — | 1 | 5 |
Show 27 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 7 | 6 | — | — | — | 12 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 5 | — | — | — | 8 |
| Neoplasms | D009369 | — | C80 | 4 | 3 | — | — | 1 | 7 |
| Lymphoma | D008223 | — | C85.9 | 1 | 7 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 4 | 2 | — | — | — | 6 |
| Recurrence | D012008 | — | — | 1 | 6 | — | — | — | 6 |
| Hematologic neoplasms | D019337 | — | — | 3 | 2 | — | — | — | 4 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | 2 | — | — | — | 4 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | 2 | — | — | — | 4 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | 2 | — | — | — | 4 |
Show 63 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | 1 | 2 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 1 | — | — | — | — | 1 |
| Thrombocytosis | D013922 | — | D75.83 | 1 | — | — | — | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Cutaneous malignant melanoma | D000096142 | — | — | 1 | — | — | — | — | 1 |
| Second primary neoplasms | D016609 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fabry disease | D000795 | Orphanet_324 | E75.21 | — | — | — | — | 3 | 3 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 2 | 2 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | — | — | — | 1 | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 1 | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | — | — | — | — | 1 | 1 |
| Retinoblastoma | D012175 | — | — | — | — | — | — | 1 | 1 |
| Rhabdoid tumor | D018335 | — | — | — | — | — | — | 1 | 1 |
Show 34 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lampalizumab |
| INN | lampalizumab |
| Description | Lampalizumab (humanized mab) |
| Classification | Antibody |
| Drug class | ionotropic non-NMDA (N-methyl D-aspartate) glutamate receptors [AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) and/or KA (kainite antagonist) receptors]; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109408 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | UWU93Y99R3 (ChemIDplus, GSRS) |
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Safety
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