Therapeutic Area | MeSH |
---|---|
cardiovascular diseases | D002318 |
signs and symptoms pathological conditions | D013568 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TRANDATE HCT | GSK | N-019174 DISCN | 1987-04-10 | 4 products |
NORMOZIDE | Merck & Co | N-019046 DISCN | 1987-04-06 | 4 products |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
LABETALOL HYDROCHLORIDE | Hikma Pharmaceuticals | N-213330 RX | 2022-03-18 | 1 products, RLD, RS |
LABETALOL HYDROCHLORIDE IN DEXTROSE | Hikma Pharmaceuticals | N-213330 RX | 2020-11-09 | 1 products, RLD, RS |
LABETALOL HYDROCHLORIDE IN SODIUM CHLORIDE | Hikma Pharmaceuticals | N-213330 RX | 2020-11-09 | 3 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
labetalol hcl in dextrose labetalol hcl in sodium chloride | New Drug Application | 2020-12-21 |
trandate | New Drug Application | 2009-12-14 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pre-eclampsia | D011225 | EFO_0000668 | O14 | 3 | 3 | 2 | 5 | 4 | 15 |
Hypertension | D006973 | EFO_0000537 | I10 | 2 | 2 | 3 | 2 | 7 | 14 |
Pregnancy-induced hypertension | D046110 | — | O13 | — | 2 | 3 | 6 | 1 | 11 |
Heart failure | D006333 | HP_0001635 | I50 | — | — | — | 3 | 2 | 5 |
Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 4 | — | 4 |
Ischemic stroke | D000083242 | — | — | — | 1 | 1 | 2 | — | 4 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | 1 | 2 |
Diastolic heart failure | D054144 | EFO_1000899 | I50.30 | — | — | — | 2 | — | 2 |
Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | 2 | — | 2 |
Laparoscopy | D010535 | — | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cerebral hemorrhage | D002543 | — | — | — | 2 | 1 | — | 2 | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Stroke | D020521 | EFO_0000712 | I63.9 | — | 3 | — | — | 2 | 5 |
Blood pressure | D001794 | EFO_0004325 | — | — | 3 | — | — | — | 3 |
Pheochromocytoma | D010673 | — | — | — | 1 | — | — | — | 1 |
Postoperative pain | D010149 | — | G89.18 | 1 | 1 | — | — | — | 1 |
Heart rate | D006339 | EFO_0004326 | — | — | 1 | — | — | — | 1 |
Proteinuria | D011507 | HP_0000093 | R80 | 1 | 1 | — | — | — | 1 |
Craniotomy | D003399 | — | — | 1 | 1 | — | — | — | 1 |
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 1 | — | — | — | 1 |
Tobacco use disorder | D014029 | — | F17 | — | 1 | — | — | — | 1 |
Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Morbid obesity | D009767 | EFO_0001074 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 2 | 2 |
Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 2 | 2 |
Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 2 | 2 |
Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
Pneumonia | D011014 | EFO_0003106 | — | — | — | — | — | 2 | 2 |
Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | — | — | 2 | 2 |
Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 2 | 2 |
Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
Hypokalemia | D007008 | HP_0002900 | E87.6 | — | — | — | — | 2 | 2 |
Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | — | 2 | 2 |
Drug common name | Labetalol |
INN | labetalol |
Description | Labetalol is a diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure. It has a role as an antihypertensive agent, a sympatholytic agent, an alpha-adrenergic antagonist and a beta-adrenergic antagonist. It contains a (R,R)-labetalol, a (S,S)-labetalol, a (R,S)-labetolol and a (S,R)-labetolol. |
Classification | Small molecule |
Drug class | combined alpha and beta blockers |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(CCc1ccccc1)NCC(O)c1ccc(O)c(C(N)=O)c1 |
PDB | — |
CAS-ID | 36894-69-6 |
RxCUI | — |
ChEMBL ID | CHEMBL429 |
ChEBI ID | 6343 |
PubChem CID | 3869 |
DrugBank | DB00598 |
UNII ID | R5H8897N95 (ChemIDplus, GSRS) |