LUVADAXISTAT
Luvadaxistat is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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FDA approval date
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Commercial
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 3 | — | — | — | 4 |
| Ataxia | D001259 | — | R27.0 | 1 | 1 | — | — | — | 2 |
| Cerebellar ataxia | D002524 | — | — | 1 | 1 | — | — | — | 2 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LUVADAXISTAT |
| INN | luvadaxistat |
| Description | Luvadaxistat is an experimental drug that works as a D-amino acid oxidase inhibitor and is supposed to increase NMDA receptor functionality. It is developed to treat Friedrich ataxia and negative symptoms of schizophrenia.
|
| Classification | Small molecule |
| Drug class | enzyme inhibitors: D-amino acid oxidase (DAAO) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]nc(CCc2ccc(C(F)(F)F)cc2)cc1O |
Identifiers
| PDB | — |
| CAS-ID | 1425511-32-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2338801 |
| ChEBI ID | — |
| PubChem CID | 71270546 |
| DrugBank | DB16067 |
| UNII ID | 76IC00YRVR (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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