LIFIRAFENIB
Lifirafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase A-Raf, epidermal growth factor receptor, and serine/threonine-protein kinase B-raf.
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Commercial
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LIFIRAFENIB |
| INN | lifirafenib |
| Description | Lifirafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase A-Raf, epidermal growth factor receptor, and serine/threonine-protein kinase B-raf. |
| Classification | Small molecule |
| Drug class | rapidly accelerated fibrosarcoma (RAF) kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3[C@H](O4)[C@H]3c3nc4cc(C(F)(F)F)ccc4[nH]3)ccnc2N1 |
Identifiers
| PDB | — |
| CAS-ID | 1446090-77-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4209157 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 8762XZS5ZF (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ARAF
ARAF
EGFR
EGFR
BRAF
BRAF
Organism
Homo sapiens
Gene name
ARAF
Gene synonyms
ARAF1, PKS, PKS2
NCBI Gene ID
Protein name
serine/threonine-protein kinase A-Raf
Protein synonyms
A-Raf proto-oncogene serine/threonine-protein kinase, Oncogene ARAF1, Proto-oncogene A-Raf, Proto-oncogene A-Raf-1, Proto-oncogene Pks, Ras-binding protein DA-Raf, v-raf murine sarcoma 3611 viral oncogene homolog 1, v-raf murine sarcoma 3611 viral oncogene-like protein
Uniprot ID
Mouse ortholog
Araf (11836)
serine/threonine-protein kinase A-Raf (Q9DBU7)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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